Open AccessA biosensor for the activity of the “sheddase” TACE (ADAM17) reveals novel and cell type–specific mechanisms of TACE activation
Author(s) -
Douglas A. Chapnick,
Eric Bunker,
Xuedong Liu
Publication year - 2015
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.2005680
Subject(s) - microbiology and biotechnology , förster resonance energy transfer , extracellular , cleavage (geology) , mapk/erk pathway , kinase , cytoskeleton , signal transduction , chemistry , disintegrin , cell , metalloproteinase , biology , biochemistry , enzyme , fluorescence , paleontology , physics , quantum mechanics , fracture (geology)
A FRET-based sensor reports the spatiotemporal dynamics of the protease TACE in live cells.
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