Open AccessPhosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition
Author(s) -
Yi Xie,
Jin Yu,
Bethany L. Merenick,
Min Ding,
Kristina M. Fetalvero,
Róbert Wágner,
Alice Mai,
Scott Gleim,
David Tucker,
Morris J. Birnbaum,
Bryan A. Ballif,
Amelia K. Luciano,
William C. Sessa,
Eva M. Rzucidlo,
Richard J. Powell,
Lin Hou,
Hongyu Zhao,
John Hwa,
Jun Yu,
Kathleen A. Martin
Publication year - 2015
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.2005482
Subject(s) - vascular smooth muscle , microbiology and biotechnology , phosphorylation , mtorc1 , transcription factor , cell growth , chemistry , biology , medicine , endocrinology , smooth muscle , gene , biochemistry , protein kinase b
Increasing the activity of the transcription factor GATA-6 prevents excessive proliferation of vascular smooth muscle cells in injured blood vessels.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom