Open AccessTREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1
Author(s) -
Qisheng Peng,
S. Malhotra,
James A. Torchia,
William G. Kerr,
K. Mark Coggeshall,
Mary Beth Humphrey
Publication year - 2010
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.2000500
Subject(s) - microbiology and biotechnology , syk , trem2 , signal transducing adaptor protein , signal transduction , receptor , chemistry , biology , tyrosine kinase , biochemistry , myeloid cells
The inositol phosphatase SHIP1 binds to a receptor-adaptor complex on osteoclasts to prevent recruitment of PI3K and inhibit receptor signaling.
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