Open AccessHinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility
Author(s) -
Christian M. Orr,
Hayden Fisher,
Xiaojie Yu,
H. T. Claude Chan,
Yunyun Gao,
Patrick J. Duriez,
Steven G. Booth,
Isabel Elliott,
Tatyana Inzhelevskaya,
Ian Mockridge,
Christine A. Penfold,
Armin Wagner,
Martin J. Glennie,
Ann L. White,
Jonathan W. Essex,
Arwen R. Pearson,
Mark S. Cragg,
Ivo Tews
Publication year - 2022
Publication title -
science immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.83
H-Index - 51
ISSN - 2470-9468
DOI - 10.1126/sciimmunol.abm3723
Subject(s) - epitope , receptor , monoclonal antibody , antibody , signal transduction , protein structure , microbiology and biotechnology , biology , immune system , chemistry , computational biology , biochemistry , immunology
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