Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths | Zendy

Paul Bastard | Zendy; Adrian Gervais | Zendy; Tom Le Voyer | Zendy; Jérémie Rosain | Zendy; Quentin Philippot | Zendy; Jérémy Manry | Zendy; Eleftherios Michailidis | Zendy; Hans-Heinrich Hoffmann | Zendy; Shohei Eto | Zendy; Marina García-Prat | Zendy; Lucy Bizien | Zendy; Alba Parra-Martínez | Zendy; Rui Yang | Zendy; Liis Haljasmägi | Zendy; Mélanie Migaud | Zendy; Karita Särekannu | Zendy; Julia Maslovskaja | Zendy; Nicolas de Prost | Zendy; Yacine Tandjaoui-Lambiotte | Zendy; CharlesÉdouard Luyt | Zendy; Blanca Amador-Borrero | Zendy; Alexandre Gaudet | Zendy; Julien Poissy | Zendy; Pascal Morel | Zendy; Pascale Richard | Zendy; Fabrice Cognasse | Zendy; Jesús Troya | Zendy; Sophie TrouilletAssant | Zendy; Alexandre Bélot | Zendy; Kahina Saker | Zendy; Pierre Garçon | Zendy; Jacques G. Rivière | Zendy; JeanChristophe Lagier | Zendy; Stéphanie Gentile | Zendy; Lindsey B. Rosen | Zendy; Elana Shaw | Zendy; Tomohiro Morio | Zendy; Junko Tanaka | Zendy; David Dalmau | Zendy; PierreLouis Tharaux | Zendy; D. Sène | Zendy; Alain Stépanian | Zendy; Bruno Mégarbane | Zendy; Vasiliki Triantafyllia | Zendy; Arnaud Fekkar | Zendy; James R. Heath | Zendy; José Luis Franco | Zendy; JuanManuel Anaya | Zendy; Jordi SoléViolán | Zendy; Luisa Imberti | Zendy; Andrea Biondi | Zendy; Paolo Bonfanti | Zendy; Riccardo Castagnoli | Zendy; Ottavia M. Delmonte | Zendy; Yu Zhang | Zendy; Andrew L. Snow | Zendy; Steven M. Holland | Zendy; Catherine M. Biggs | Zendy; Marcela MoncadaVélez | Zendy; Andrés A. Arias | Zendy; Lazaro Lorenzo | Zendy; Soraya Boucherit | Zendy; Boubacar Coulibaly | Zendy; Dany Anglicheau | Zendy; Anna M. Planas | Zendy; Filomeen Haerynck | Zendy; Sotiriјa Duvlis | Zendy; Robert L. Nussbaum | Zendy; Tayfun Özçelık | Zendy; Sevgi Keleş | Zendy; Ahmed Aziz Bousfiha | Zendy; Jalila El Bakkouri | Zendy; Carolina RamírezSantana | Zendy; Stéphane Paul | Zendy; Qiang PanHammarström | Zendy; Lennart Hammarström | Zendy; Annabelle Dupont | Zendy; Alina Kurolap | Zendy; Christine N. Metz | Zendy; Alessandro Aiuti | Zendy; Giorgio Casari | Zendy; Vito Lampasona | Zendy; Fabio Ciceri | Zendy; Lucila Akune Barreiros | Zendy; Elena DomínguezGarrido | Zendy; Mateus Vidigal | Zendy; Mayana Zatz | Zendy; Diederik van de Beek | Zendy; Sabina Sahanic | Zendy; Ivan Tancevski | Zendy; Yuriy Stepanovskyy | Zendy; Oksana Boyarchuk | Zendy; Yoko Nukui | Zendy; Miyuki Tsumura | Zendy; Loreto Vidaur | Zendy; Stuart G. Tangye | Zendy; Sonia Burrel | Zendy; Darragh Duffy | Zendy; Lluís QuintanaMurci | Zendy; Adam Klocperk | Zendy; Nelli Y. Kann | Zendy; Anna Shcherbina | Zendy; YL Lau | Zendy; Daniel Leung | Zendy; Matthieu Coulongeat | Zendy; Julien Marlet | Zendy; Rutger Koning | Zendy; Luis Felipe Reyes | Zendy; Angélique ChauvineauGrenier | Zendy; Fabienne Venet | Zendy; Guillaume Monneret | Zendy; Michel C. Nussenzweig | Zendy; Romain Arrestier | Zendy; Idris Boudhabhay | Zendy; Hagit Baris Feldman | Zendy; David Hagin | Zendy; Joost Wauters | Zendy; Isabelle Meyts | Zendy; Adam H. Dyer | Zendy; Seán Kennelly | Zendy; Nollaig M. Bourke | Zendy; Rabih Halwani | Zendy; Narjes Saheb SharifAskari | Zendy; Karim Dorgham | Zendy; Jérôme Sallette | Zendy; Souad Mehlal Sedkaoui | Zendy; Suzan A. AlKhater | Zendy; Raúl RigoBonnin | Zendy; Francisco Morandeira | Zendy; Lucie Roussel | Zendy; Donald C. Vinh | Zendy; Sisse Rye Ostrowski | Zendy; Antônio CondinoNeto | Zendy; Carolina Prando | Zendy; Анастасія Бондаренко | Zendy; András N. Spaan | Zendy; Laurent Gilardin | Zendy; Jacques Fellay | Zendy; Stanislas Lyonnet | Zendy; Kaya Bilgüvar | Zendy; Richard P. Lifton | Zendy; Shrikant Mane | Zendy; Mark S. Anderson | Zendy; Bertrand Boisson | Zendy; Vivien Béziat | Zendy; ShenYing Zhang | Zendy; Evangelos Andreakos | Zendy; Olivier Hermine | Zendy; Aurora Pujol | Zendy; Pärt Peterson | Zendy; Trine H. Mogensen | Zendy; Lee Rowen | Zendy; James Mond | Zendy; Stéphanie Debette | Zendy; Xavier de Lamballerie | Zendy; Xavier Duval | Zendy; France Mentré | Zendy; Marie Zins | Zendy; Pere SolerPalacín | Zendy; Roger Colobrán | Zendy; Guy Gorochov | Zendy; Xavier Solanich | Zendy; Sophie Susen | Zendy; Javier MartínezPicado | Zendy; Didier Raoult | Zendy; Marc Vasse | Zendy; Peter K. Gregersen | Zendy; Lorenzo Piemonti | Zendy; Carlos RodríguezGallego | Zendy; Luigi D. Notarangelo | Zendy; Helen C. Su | Zendy; Kai Kisand | Zendy; Satoshi Okada | Zendy; Anne Puel | Zendy; Emmanuelle Jouanguy | Zendy; Charles M. Rice | Zendy; Pierre Tiberghien | Zendy; Qian Zhang | Zendy; Aurélie Cobat | Zendy; Laurent Abel | Zendy; JeanLaurent Casanova | Zendy

Open Access

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Author(s) -

Paul Bastard,

Adrian Gervais,

Tom Le Voyer,

Jérémie Rosain,

Quentin Philippot,

Jérémy Manry,

Eleftherios Michailidis,

Hans-Heinrich Hoffmann,

Shohei Eto,

Marina García-Prat,

Lucy Bizien,

Alba Parra-Martínez,

Rui Yang,

Liis Haljasmägi,

Mélanie Migaud,

Karita Särekannu,

Julia Maslovskaja,

Nicolas de Prost,

Yacine Tandjaoui-Lambiotte,

CharlesÉdouard Luyt,

Blanca Amador-Borrero,

Alexandre Gaudet,

Julien Poissy,

Pascal Morel,

Pascale Richard,

Fabrice Cognasse,

Jesús Troya,

Sophie TrouilletAssant,

Alexandre Bélot,

Kahina Saker,

Pierre Garçon,

Jacques G. Rivière,

JeanChristophe Lagier,

Stéphanie Gentile,

Lindsey B. Rosen,

Elana Shaw,

Tomohiro Morio,

Junko Tanaka,

David Dalmau,

PierreLouis Tharaux,

D. Sène,

Alain Stépanian,

Bruno Mégarbane,

Vasiliki Triantafyllia,

Arnaud Fekkar,

James R. Heath,

José Luis Franco,

JuanManuel Anaya,

Jordi SoléViolán,

Luisa Imberti,

Andrea Biondi,

Paolo Bonfanti,

Riccardo Castagnoli,

Ottavia M. Delmonte,

Yu Zhang,

Andrew L. Snow,

Steven M. Holland,

Catherine M. Biggs,

Marcela MoncadaVélez,

Andrés A. Arias,

Lazaro Lorenzo,

Soraya Boucherit,

Boubacar Coulibaly,

Dany Anglicheau,

Anna M. Planas,

Filomeen Haerynck,

Sotiriјa Duvlis,

Robert L. Nussbaum,

Tayfun Özçelık,

Sevgi Keleş,

Ahmed Aziz Bousfiha,

Jalila El Bakkouri,

Carolina RamírezSantana,

Stéphane Paul,

Qiang PanHammarström,

Lennart Hammarström,

Annabelle Dupont,

Alina Kurolap,

Christine N. Metz,

Alessandro Aiuti,

Giorgio Casari,

Vito Lampasona,

Fabio Ciceri,

Lucila Akune Barreiros,

Elena DomínguezGarrido,

Mateus Vidigal,

Mayana Zatz,

Diederik van de Beek,

Sabina Sahanic,

Ivan Tancevski,

Yuriy Stepanovskyy,

Oksana Boyarchuk,

Yoko Nukui,

Miyuki Tsumura,

Loreto Vidaur,

Stuart G. Tangye,

Sonia Burrel,

Darragh Duffy,

Lluís QuintanaMurci,

Adam Klocperk,

Nelli Y. Kann,

Anna Shcherbina,

YL Lau,

Daniel Leung,

Matthieu Coulongeat,

Julien Marlet,

Rutger Koning,

Luis Felipe Reyes,

Angélique ChauvineauGrenier,

Fabienne Venet,

Guillaume Monneret,

Michel C. Nussenzweig,

Romain Arrestier,

Idris Boudhabhay,

Hagit Baris Feldman,

David Hagin,

Joost Wauters,

Isabelle Meyts,

Adam H. Dyer,

Seán Kennelly,

Nollaig M. Bourke,

Rabih Halwani,

Narjes Saheb SharifAskari,

Karim Dorgham,

Jérôme Sallette,

Souad Mehlal Sedkaoui,

Suzan A. AlKhater,

Raúl RigoBonnin,

Francisco Morandeira,

Lucie Roussel,

Donald C. Vinh,

Sisse Rye Ostrowski,

Antônio CondinoNeto,

Carolina Prando,

Анастасія Бондаренко,

András N. Spaan,

Laurent Gilardin,

Jacques Fellay,

Stanislas Lyonnet,

Kaya Bilgüvar,

Richard P. Lifton,

Shrikant Mane,

Mark S. Anderson,

Bertrand Boisson,

Vivien Béziat,

ShenYing Zhang,

Evangelos Andreakos,

Olivier Hermine,

Aurora Pujol,

Pärt Peterson,

Trine H. Mogensen,

Lee Rowen,

James Mond,

Stéphanie Debette,

Xavier de Lamballerie,

Xavier Duval,

France Mentré,

Marie Zins,

Pere SolerPalacín,

Roger Colobrán,

Guy Gorochov,

Xavier Solanich,

Sophie Susen,

Javier MartínezPicado,

Didier Raoult,

Marc Vasse,

Peter K. Gregersen,

Lorenzo Piemonti,

Carlos RodríguezGallego,

Luigi D. Notarangelo,

Helen C. Su,

Kai Kisand,

Satoshi Okada,

Anne Puel,

Emmanuelle Jouanguy,

Charles M. Rice,

Pierre Tiberghien,

Qian Zhang,

Aurélie Cobat,

Laurent Abel,

JeanLaurent Casanova

Publication year - 2021

Publication title -

science immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.83

H-Index - 51

ISSN - 2470-9468

DOI - 10.1126/sciimmunol.abl4340

Subject(s) - neutralizing antibody , asymptomatic , medicine , autoantibody , antibody , covid-19 , population , pneumonia , immunology , virology , gastroenterology , disease , environmental health , infectious disease (medical specialty)

Autoantibodies neutralizing type I IFNs increase in prevalence over 60 years of age and underlie about 20% of all fatal COVID-19 cases.

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