SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection | Zendy

Daniel M. Altmann | Zendy; Rosemary J. Boyton | Zendy

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SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection

Author(s) -

Daniel M. Altmann,

Rosemary J. Boyton

Publication year - 2020

Publication title -

science immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.83

H-Index - 51

ISSN - 2470-9468

DOI - 10.1126/sciimmunol.abd6160

Subject(s) - immunity , virology , covid-19 , immunology , biology , function (biology) , innate immune system , medicine , immune system , genetics , disease , pathology , infectious disease (medical specialty)

In efforts to synthesize a clear understanding of SARS-CoV-2 protective immunity, antibody analysis has been paralleled by T cell studies across asymptomatic, mild and severe COVID-19. Defining CD4 and CD8 effector functions in protection is important considering that antibody responses appear short-lived and T cell memory is potentially more durable. To fully understand population level immunity, screening for both antibody and T cell immunity using standardized testing methods would be beneficial.

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