Origins and clonal convergence of gastrointestinal IgE + B cells in human peanut allergy | Zendy

Ramona A. Hoh | Zendy; Shilpa A. Joshi | Zendy; Ji-Yeun Lee | Zendy; Brock A. Martin | Zendy; Sushama Varma | Zendy; Shirley Kwok | Zendy; Sandra C. A. Nielsen | Zendy; Parastu Nejad | Zendy; Emily Haraguchi | Zendy; Priya S. Dixit | Zendy; Swetha V. Shutthanandan | Zendy; Krishna M. Roskin | Zendy; Wenming Zhang | Zendy; Dana Tupa | Zendy; Bryan Bunning | Zendy; Monali Manohar | Zendy; Robert Tibshirani | Zendy; Nielsen FernandezBecker | Zendy; Neeraja Kambham | Zendy; Robert B. West | Zendy; Robert G. Hamilton | Zendy; Mindy Tsai | Zendy; Stephen J. Galli | Zendy; R. Sharon Chinthrajah | Zendy; Kari C. Nadeau | Zendy; Scott D. Boyd | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Origins and clonal convergence of gastrointestinal IgE ⁺ B cells in human peanut allergy

Author(s) -

Ramona A. Hoh,

Shilpa A. Joshi,

Ji-Yeun Lee,

Brock A. Martin,

Sushama Varma,

Shirley Kwok,

Sandra C. A. Nielsen,

Parastu Nejad,

Emily Haraguchi,

Priya S. Dixit,

Swetha V. Shutthanandan,

Krishna M. Roskin,

Wenming Zhang,

Dana Tupa,

Bryan Bunning,

Monali Manohar,

Robert Tibshirani,

Nielsen FernandezBecker,

Neeraja Kambham,

Robert B. West,

Robert G. Hamilton,

Mindy Tsai,

Stephen J. Galli,

R. Sharon Chinthrajah,

Kari C. Nadeau,

Scott D. Boyd

Publication year - 2020

Publication title -

science immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.83

H-Index - 51

ISSN - 2470-9468

DOI - 10.1126/sciimmunol.aay4209

Subject(s) - immunoglobulin e , immunology , cd23 , biology , isotype , allergy , antibody , food allergy , allergen , duodenum , gastrointestinal tract , stomach , medicine , monoclonal antibody , biochemistry

B cells in human food allergy have been studied predominantly in the blood. Little is known about IgE + B cells or plasma cells in tissues exposed to dietary antigens. We characterized IgE + clones in blood, stomach, duodenum, and esophagus of 19 peanut-allergic patients, using high-throughput DNA sequencing. IgE + cells in allergic patients are enriched in stomach and duodenum, and have a plasma cell phenotype. Clonally related IgE + and non-IgE-expressing cell frequencies in tissues suggest local isotype switching, including transitions between IgA and IgE isotypes. Highly similar antibody sequences specific for peanut allergen Ara h 2 are shared between patients, indicating that common immunoglobulin genetic rearrangements may contribute to pathogenesis. These data define the gastrointestinal tract as a reservoir of IgE + B lineage cells in food allergy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research