Open AccessConversion of antigen-specific effector/memory T cells into Foxp3-expressing T reg cells by inhibition of CDK8/19
Author(s) -
Masahiko Akamatsu,
Norihisa Mikami,
Naganari Ohkura,
Ryoji Kawakami,
Yohko Kitagawa,
Atsushi Sugimoto,
Keiji Hirota,
Naoto Nakamura,
Satoru Ujihara,
T. Kurosaki,
Hisao Hamaguchi,
Hironori Harada,
Guliang Xia,
Yoshiaki Morita,
Ichiro Aramori,
Shuh Narumiya,
Shimon Sakaguchi
Publication year - 2019
Publication title -
science immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.83
H-Index - 51
ISSN - 2470-9468
DOI - 10.1126/sciimmunol.aaw2707
Subject(s) - effector , foxp3 , biology , antigen , immunology , microbiology and biotechnology , treg cell , il 2 receptor , t cell , immune system
CDK8/19 inhibitors can convert naïve and memory/effector T cells into Treg cells capable of treating immunological diseases.
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