Open AccessThe probacterial effect of type I interferon signaling requires its own negative regulator USP18
Author(s) -
Namir Shaabani,
Nadine Honke,
Nhan Nguyen,
Zhe Huang,
Keiichiro Arimoto,
Daniel C. Lazar,
Taylor K. Loe,
Karl S. Lang,
Marco Prinz,
KlausPeter Knobeloch,
DongEr Zhang,
John R. Teijaro
Publication year - 2018
Publication title -
science immunology
Language(s) - English
Resource type - Journals
ISSN - 2470-9468
DOI - 10.1126/sciimmunol.aau2125
Subject(s) - effector , regulator , interferon , negative regulator , biology , microbiology and biotechnology , signal transduction , key (lock) , interferon type i , gene , immunology , genetics , ecology
USP18 acts as a key effector molecule downstream of IFN-I signaling to promote primary and secondary bacterial infections.
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