Open AccessSuppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity
Author(s) -
Houjun Xia,
Wei Wang,
Joel Crespo,
Ilona Kryczek,
Wei Li,
Shuang Wei,
Zhaoqun Bian,
Tomasz Maj,
MingXiao He,
J Rebecca Liu,
YouWen He,
Ramandeep Rattan,
Adnan Munkarah,
JunLin Guan,
Weiping Zou
Publication year - 2017
Publication title -
science immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.83
H-Index - 51
ISSN - 2470-9468
DOI - 10.1126/sciimmunol.aan4631
Subject(s) - autophagy , apoptosis , microbiology and biotechnology , immunity , reactive oxygen species , biology , programmed cell death , cancer research , immune system , chemistry , immunology , biochemistry
Tumor-derived lactate induced naïve T cell apoptosis via suppressing FIP200 expression and autophagy formation, resulting in mitochondria activation and imbalance of Bcl-2 family members in T cells.
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