Eomesodermin promotes the development of type 1 regulatory T (T R 1) cells | Zendy

Ping Zhang | Zendy; Jason S. Lee | Zendy; Kate H. Gartlan | Zendy; Iona S. Schuster | Zendy; Iain Comerford | Zendy; Antiopi Varelias | Zendy; Md Ashik Ullah | Zendy; Slavica Vučković | Zendy; Motoko Koyama | Zendy; Rachel D. Kuns | Zendy; Kelly R. Locke | Zendy; Kirrilee Beckett | Zendy; Stuart D. Olver | Zendy; Luke Samson | Zendy; Marcela Montes de | Zendy; Fabian de Labastida Rivera | Zendy; Andrew D. Clouston | Zendy; Gabrielle T. Belz | Zendy; Bruce R. Blazar | Zendy; Kelli P. A. MacDonald | Zendy; Shaun R. McColl | Zendy; Ranjeny Thomas | Zendy; Christian Engwerda | Zendy; Mariapia A. DegliEsposti | Zendy; Axel Kallies | Zendy; SiokKeen Tey | Zendy; Geoffrey R. Hill | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Eomesodermin promotes the development of type 1 regulatory T (T _R 1) cells

Author(s) -

Ping Zhang,

Jason S. Lee,

Kate H. Gartlan,

Iona S. Schuster,

Iain Comerford,

Antiopi Varelias,

Md Ashik Ullah,

Slavica Vučković,

Motoko Koyama,

Rachel D. Kuns,

Kelly R. Locke,

Kirrilee Beckett,

Stuart D. Olver,

Luke Samson,

Marcela Montes de,

Fabian de Labastida Rivera,

Andrew D. Clouston,

Gabrielle T. Belz,

Bruce R. Blazar,

Kelli P. A. MacDonald,

Shaun R. McColl,

Ranjeny Thomas,

Christian Engwerda,

Mariapia A. DegliEsposti,

Axel Kallies,

SiokKeen Tey,

Geoffrey R. Hill

Publication year - 2017

Publication title -

science immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.83

H-Index - 51

ISSN - 2470-9468

DOI - 10.1126/sciimmunol.aah7152

Subject(s) - foxp3 , transcription factor , biology , microbiology and biotechnology , immunology , cellular differentiation , population , stem cell , immune system , medicine , genetics , gene , environmental health

Type 1 regulatory T (T R 1) cells are Foxp3 - interleukin-10 (IL-10)-producing CD4 + T cells with potent immunosuppressive properties, but their requirements for lineage development have remained elusive. We show that T R 1 cells constitute the most abundant regulatory population after allogeneic bone marrow transplantation (BMT), express the transcription factor Eomesodermin (Eomes), and are critical for the prevention of graft-versus-host disease. We demonstrate that Eomes is required for T R 1 cell differentiation, during which it acts in concert with the transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) by transcriptionally activating IL-10 expression and repressing differentiation into other T helper cell lineages. We further show that Eomes induction in T R 1 cells requires T-bet and donor macrophage-derived IL-27. Thus, we define the cellular and transcriptional control of T R 1 cell differentiation during BMT, opening new avenues to therapeutic manipulation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research