Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant | Zendy

Paul Elliott | Zendy; David Haw | Zendy; Haowei Wang | Zendy; Oliver Eales | Zendy; Caroline E. Walters | Zendy; Kylie E. C. Ainslie | Zendy; Christina Atchison | Zendy; Claudio Fronterrè | Zendy; Peter J. Diggle | Zendy; Andrew J. Page | Zendy; Alexander J. Trotter | Zendy; Sophie J. Prosolek | Zendy; Deborah Ashby | Zendy; Christl A. Donnelly | Zendy; William Barclay | Zendy; Graham P. Taylor | Zendy; Graham Cooke | Zendy; Helen Ward | Zendy; Ara Darzi | Zendy; Steven Riley | Zendy

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Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant

Author(s) -

Paul Elliott,

David Haw,

Haowei Wang,

Oliver Eales,

Caroline E. Walters,

Kylie E. C. Ainslie,

Christina Atchison,

Claudio Fronterrè,

Peter J. Diggle,

Andrew J. Page,

Alexander J. Trotter,

Sophie J. Prosolek,

Deborah Ashby,

Christl A. Donnelly,

William Barclay,

Graham P. Taylor,

Graham Cooke,

Helen Ward,

Ara Darzi,

Steven Riley

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abl9551

Subject(s) - vaccination , pandemic , immunity , covid-19 , herd immunity , transmission (telecommunications) , disease , delta , demography , virology , respiratory illness , biology , medicine , immunology , infectious disease (medical specialty) , respiratory system , immune system , outbreak , aerospace engineering , sociology , electrical engineering , engineering

Vaccination and disease The United Kingdom has high rates of vaccination for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exceeding 80% of adults. As immunity wanes and social distancing is relaxed, how are rates of illness and severe disease affected by more infectious variants? Elliottet al . used reverse transcription PCR data from the REACT-1 study, which showed exponential transmission as the Alpha variant (B.1.1.7) was replaced by the Delta variant (B.1.617.2). After adjusting for age and other variables, vaccine effectiveness for the new variant averaged 55% in June and July of 2020. Despite the slower growth of the pandemic in the summer, it looks as if increased indoor mixing in the autumn will sustain transmission of the Delta variant despite high levels of adult vaccination. —CA

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