Open AccessRNA stabilization by a poly(A) tail 3′-end binding pocket and other modes of poly(A)-RNA interaction
Author(s) -
SeyedFakhreddin Torabi,
Anand T. Vaidya,
Kazimierz T. Tycowski,
Suzanne J. DeGregorio,
Jimin Wang,
Mei-Di Shu,
Thomas A. Steitz,
Joan A. Steitz
Publication year - 2021
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.abe6523
Subject(s) - rna , directionality , polyadenylation , base pair , riboswitch , messenger rna , duplex (building) , binding site , nucleic acid structure , biophysics , rna binding protein , nucleotide , chemistry , biology , dna , microbiology and biotechnology , genetics , non coding rna , gene
Poly(A) and RNA: More ways to interact One of the most conserved RNA modifications across organisms is the addition of a polyadenosine, or poly(A), tail to the 3′ end of RNA molecules. Cis-acting RNA stabilization elements, such as the triplex-forming element for nuclear expression (ENE), retard RNA decay, thereby controlling the maturation and abundance of cellular transcripts. Torabiet al. determined the high-resolution crystal structure of a double ENE complexed with 28-mer poly(A) to reveal new modes of the RNA-RNA interaction, including a pocket motif that protects the extreme 3′ end of the poly(A) tail. Discovery of such interactions opens new venues to better understanding poly(A) tail function in RNA biology.Science , this issue p.eabe6523
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