Preexisting and de novo humoral immunity to SARS-CoV-2 in humans | Zendy

Kevin W. Ng | Zendy; Nikhil Faulkner | Zendy; Georgina H. Cornish | Zendy; Annachiara Rosa | Zendy; Ruth Harvey | Zendy; Saira Hussain | Zendy; Rachel Ulferts | Zendy; Christopher Earl | Zendy; Antoni G. Wrobel | Zendy; D.J. Benton | Zendy; Chloë Roustan | Zendy; William Bolland | Zendy; R. Houston Thompson | Zendy; Ana AguaDoce | Zendy; Philip Hobson | Zendy; Judith Heaney | Zendy; Hannah M. Rickman | Zendy; Stavroula Paraskevopoulou | Zendy; Catherine Houlihan | Zendy; Kirsty Thomson | Zendy; Emilie Sanchez | Zendy; Gee Yen Shin | Zendy; Moira J. Spyer | Zendy; Dhira Joshi | Zendy; Nicola O’Reilly | Zendy; P.A. Walker | Zendy; Svend Kjær | Zendy; Andrew Riddell | Zendy; Catherine Moore | Zendy; Bethany R. Jebson | Zendy; Meredyth Wilkinson | Zendy; Lucy Marshall | Zendy; Elizabeth C. Rosser | Zendy; Anna Radziszewska | Zendy; Hannah Peckham | Zendy; Coziana Ciurtin | Zendy; Lucy R. Wedderburn | Zendy; Rupert Beale | Zendy; Charles Swanton | Zendy; Sonia Gandhi | Zendy; Brigitta Stockinger | Zendy; John W. McCauley | Zendy; S.J. Gamblin | Zendy; Laura E. McCoy | Zendy; Peter Cherepanov | Zendy; Eleni Nastouli | Zendy; George Kassiotis | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Author(s) -

Kevin W. Ng,

Nikhil Faulkner,

Georgina H. Cornish,

Annachiara Rosa,

Ruth Harvey,

Saira Hussain,

Rachel Ulferts,

Christopher Earl,

Antoni G. Wrobel,

D.J. Benton,

Chloë Roustan,

William Bolland,

R. Houston Thompson,

Ana AguaDoce,

Philip Hobson,

Judith Heaney,

Hannah M. Rickman,

Stavroula Paraskevopoulou,

Catherine Houlihan,

Kirsty Thomson,

Emilie Sanchez,

Gee Yen Shin,

Moira J. Spyer,

Dhira Joshi,

Nicola O’Reilly,

P.A. Walker,

Svend Kjær,

Andrew Riddell,

Catherine Moore,

Bethany R. Jebson,

Meredyth Wilkinson,

Lucy Marshall,

Elizabeth C. Rosser,

Anna Radziszewska,

Hannah Peckham,

Coziana Ciurtin,

Lucy R. Wedderburn,

Rupert Beale,

Charles Swanton,

Sonia Gandhi,

Brigitta Stockinger,

John W. McCauley,

S.J. Gamblin,

Laura E. McCoy,

Peter Cherepanov,

Eleni Nastouli,

George Kassiotis

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abe1107

Subject(s) - antibody , immunity , humoral immunity , immunology , virology , biology , immune system , covid-19 , immunoglobulin g , herd immunity , medicine , vaccination , infectious disease (medical specialty) , disease , pathology

Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)-reactive antibodies were detectable using a flow cytometry-based method in SARS-CoV-2-uninfected individuals and were particularly prevalent in children and adolescents. They were predominantly of the immunoglobulin G (IgG) class and targeted the S2 subunit. By contrast, SARS-CoV-2 infection induced higher titers of SARS-CoV-2 S-reactive IgG antibodies targeting both the S1 and S2 subunits, and concomitant IgM and IgA antibodies, lasting throughout the observation period. SARS-CoV-2-uninfected donor sera exhibited specific neutralizing activity against SARS-CoV-2 and SARS-CoV-2 S pseudotypes. Distinguishing preexisting and de novo immunity will be critical for our understanding of susceptibility to and the natural course of SARS-CoV-2 infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research