Mechanism of membrane-tethered mitochondrial protein synthesis | Zendy

Yuzuru Itoh | Zendy; Juni Andréll | Zendy; Austin Choi | Zendy; Uwe Richter | Zendy; Priyanka Maiti | Zendy; Robert B. Best | Zendy; Antoni Barrientos | Zendy; Brendan J. Battersby | Zendy; Alexey Amunts | Zendy

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Mechanism of membrane-tethered mitochondrial protein synthesis

Author(s) -

Yuzuru Itoh,

Juni Andréll,

Austin Choi,

Uwe Richter,

Priyanka Maiti,

Robert B. Best,

Antoni Barrientos,

Brendan J. Battersby,

Alexey Amunts

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abe0763

Subject(s) - mitochondrial membrane transport protein , transmembrane protein , mitochondrion , microbiology and biotechnology , membrane protein , chemistry , mechanism (biology) , biophysics , inner mitochondrial membrane , protein biosynthesis , translation (biology) , membrane , biology , biochemistry , physics , gene , messenger rna , receptor , quantum mechanics

Making the energy makers Within a mitochondrion, the powerhouse of eukaryotic cells, synthesis of the specialized transmembrane proteins of the electron transport chain is performed by dedicated mitoribosomes. The mechanism by which mitoribosomes couple protein synthesis with membrane insertion is poorly understood. Itohet al. determined structures of the human mitoribosome during nascent chain synthesis while bound to its membrane insertase. These structures revealed a series of coordinated conformational changes within the polypeptide exit tunnel. The gating mechanism offers a fundamental molecular insight into how membrane proteins are synthesized in human mitochondria.Science , this issue p.846

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