Open AccessAutoantibodies against type I IFNs in patients with life-threatening COVID-19
Author(s) -
Paul Bastard,
Lindsey B. Rosen,
Qian Zhang,
Eleftherios Michailidis,
Hans-Heinrich Hoffmann,
Yu Zhang,
Karim Dorgham,
Quentin Philippot,
Jérémie Rosain,
Vivien Béziat,
Jérémy Manry,
Elana Shaw,
Liis Haljasmägi,
Pärt Peterson,
Lazaro Lorenzo,
Lucy Bizien,
Sophie TrouilletAssant,
Kerry Dobbs,
Adriana A. de Jesus,
Alexandre Bélot,
Anne Kallaste,
Émilie Catherinot,
Yacine Tandjaoui-Lambiotte,
Jérémie Le Pen,
Gaspard Kerner,
Benedetta Bigio,
Yoann Seeleuthner,
Rui Yang,
Alexandre Bolze,
András N. Spaan,
Ottavia M. Delmonte,
Michael S. Abers,
Alessandro Aiuti,
Giorgio Casari,
Vito Lampasona,
Lorenzo Piemonti,
Fabio Ciceri,
Kaya Bilgüvar,
Richard P. Lifton,
Marc Vasse,
David M. Smadja,
Mélanie Migaud,
Jérôme Hadjadj,
Benjamin Terrier,
Darragh Duffy,
Lluís QuintanaMurci,
Diederik van de Beek,
Lucie Roussel,
Donald C. Vinh,
Stuart G. Tangye,
Filomeen Haerynck,
David Dalmau,
Javier MartínezPicado,
Petter Brodin,
Michel C. Nussenzweig,
Stéphanie BoissonDupuis,
Carlos RodríguezGallego,
Guillaume Vogt,
Trine H. Mogensen,
Andrew J. Oler,
Jingwen Gu,
Peter D. Burbelo,
Jeffrey I. Cohen,
Andrea Biondi,
Laura Rachele Bettini,
Mariella D’Angiò,
Paolo Bonfanti,
Patrick Rossignol,
Julien Mayaux,
Frédéric RieuxLaucat,
Eystein S. Husebye,
Francesca Fusco,
Matilde Valeria Ursini,
Luisa Imberti,
Alessandra Sottini,
Simone Paghera,
Eugenia Quirós-Roldán,
Camillo Rossi,
Riccardo Castagnoli,
Daniela Montagna,
Amelia Licari,
Gian Luigi Marseglia,
Xavier Duval,
Jade Ghosn,
John S. Tsang,
Raphaela GoldbachMansky,
Kai Kisand,
Michail S. Lionakis,
Anne Puel,
ShenYing Zhang,
Steven M. Holland,
Guy Gorochov,
Emmanuelle Jouanguy,
Charles M. Rice,
Aurélie Cobat,
Luigi D. Notarangelo,
Laurent Abel,
Helen C. Su,
JeanLaurent Casanova,
Andrés A. Arias,
Bertrand Boisson,
Soraya Boucherit,
Jacinta Bustamante,
Marwa Chbihi,
Jie Chen,
Maya Chrabieh,
Tatiana Kochetkov,
Tom Le Voyer,
Dana Liu,
Yeleemirovskaya,
Masato Ogishi,
Dominick Papandrea,
Cécile Patissier,
Franck Rapaport,
Ma Roynard,
Natasha Vladikine,
Mark Woollett,
Peng Zhang,
Anuj Kashyap,
Li Ding,
Marita Bosticardo,
Qinlu Wang,
Sebastian Ochoa,
Hui Liu,
Samuel D. Chauvin,
Michael Stack,
Galina Koroleva,
Neha Bansal,
Clifton L. Dalgard,
Andrew L. Snow,
Jorge Abad,
Sergio Aguilera,
Özge Metin Akcan,
Ilad Alavi Darazam,
Juan C. Aldave,
Miquel Alfonso Ramos,
Seyed Alireza Nadji,
Gülsüm Alkan,
Jérôme Allardet-Servent,
Luís M. Allende,
Laia Alsina,
MarieAlexandra Alyanakian,
Blanca Amador-Borrero,
Zahir Amoura,
Arnau Antolí,
Şevket Arslan,
Sophie Assant,
Teresa Auguet,
Axelle Azot,
Fanny Bajolle,
Aurélie Baldolli,
Mayte Ballester,
Hagit Baris Feldman,
Benoı̂t Barrou,
Alexandra Beurton,
Agurtzane Bilbao,
Géraldine Blanchard-Rohner,
Ignacio Blanco,
Adeline Blandinières,
Daniel BlázquezGamero,
Markéta Bloomfield,
Mireia Bolívar-Prados,
Raphaël Borie,
Ahmed Aziz Bousfiha,
Claire Bouvattier,
Oksana Boyarchuk,
Maria Rita PassosBueno,
Juan José Cáceres Agra,
Semra Calimli,
Ruggero Capra,
Maria Carrabba,
Carlos Casasnovas,
Marion Caséris,
Martin Castelle,
Francesco Castelli,
Martín Castillo de Vera,
Mateus Vidigal de Castro,
Martin Chalumeau,
Bruno Charbit,
Matthew Pellan Cheng,
Père Clavé,
Bonaventura Clotet,
Anna Codina,
Fatih Çölkesen,
Fatma Çölkesen,
Roger Colobrán,
Cloé Comarmond,
Angelo Guido Corsico,
D.R. Darley,
Nicolás Dauby,
Stéphane Dauger,
Loïc de Pontual,
Amin Dehban,
Geoffroy Delplancq,
Alexandre Demoule,
Antonio Di Sabatino,
JeanLuc Diehl,
Stephanie Dobbelaere,
Sophie Durand,
Waleed Eldars,
Mohamed Elgamal,
Marwa H. Elnagdy,
Melike Emiroğlu,
Emine Hafize Erdeniz,
Selma Erol Aytekin,
Romain Euvrard,
Recep Evcen,
Fabio Gavarini,
Laurence Faivre,
Antonin Falck,
Muriel Fartoukh,
Morgane Faure,
Miguel FernándezArquero,
Carlos Flores,
Bruno François,
Victòria Fumadó,
Blanca GarcíaSolis,
Pascale Gaussem,
Juana Gil-Herrera,
Laurent Gilardin,
Monica Girona Alarcon,
Mònica GironaAlarcón,
JeanChristophe Goffard,
Funda Gök,
Rafaela GonzálezMontelongo,
Antoine Guerder,
Yahya Gül,
Şükrü Nail Güner,
Marta Gut,
Rabih Halwani,
Lennart Hammarström,
Nevin Hatipoğlu,
Elisa Hernández-Brito,
M.S. Holanda Peña,
Juan Pablo Horcajada,
Sami Hraiech,
L. Humbert,
Alejandro Iglesias,
Antonio Íñigo-Campos,
Matthieu Jamme,
María J. Arranz,
Iolanda Jordán,
Fikret Kanat,
Hasan Kapaklı,
Iskender Kara,
Adem Karbuz,
Kadriye Kart Yaşar,
Sevgi Keleş,
Yasemin Kendir Demirkol,
Adam Klocperk,
Zbigniew Król,
Paul Kuentz,
Mike Yat Wah Kwan,
JeanChristophe Lagier,
YL Lau,
Fleur Le Bourgeois,
YeeSin Leo,
Rafael LeónLópez,
Daniel Leung,
Michael Levin,
Michaël Levy,
Romain Lévy,
Zhi Li,
Agnès Linglart,
José M. Lorenzo-Salazar,
Céline Louapre,
Catherine Lubetzki,
CharlesÉdouard Luyt,
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Davood Mansouri,
Majid Marjani,
Jesus Marquez Pereira,
Andrea MartínNalda,
David Martínez Pueyo,
Iciar Marzana,
Alexis Mathian,
Larissa R. B. Matos,
Gail Matthews,
JeanLouis Mège,
Isabelle Melki,
Jean–François Méritet,
Isabelle Meyts,
Mehdi Mezidi,
Isabelle Migeotte,
Maude Millereux,
Tristan Mirault,
Clotilde Mircher,
Mehdi Mirsaeidi,
Abián Montesdeoca Melián,
Antonio Morales Martínez,
PierreEmmanuel Morange,
C. Mordacq,
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C Vilain,
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Frank van Baarle,
Diane Bax,
Martijn Beudel,
Harm Jan Bogaard,
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Michela Botta,
Justin de Brabander,
Godelieve de Bree,
Matthijs C. Brouwer,
Sanne de Bruin,
Marianna Bugiani,
Esther Bulle,
Osoul Chouchane,
Alex Cloherty,
Paul Elbers,
Lucas M. Fleuren,
Suzanne E. Geerlings,
Bart F. Geerts,
Teunis B. H. Geijtenbeek,
Armand R. J. Girbes,
Abraham Goorhuis,
Martin P. Grobusch,
Florianne Hafkamp,
Laura A. Hagens,
Jörg Hamann,
Vanessa Harris,
Robert Hemke,
Sabine Hermans,
Leo Heunks,
Markus W. Hollmann,
Janneke Horn,
Joppe W. Hovius,
Menno D. de Jong,
Rutger Koning,
Niels van Mourik,
Frederique Paulus,
Edgar Peters,
Tom van der Poll,
Benedikt Preckel,
Jan M. Prins,
Jorinde Raasveld,
Tom D. Y. Reijnders,
Michiel Schinkel,
Marcus J. Schultz,
Alex R. Schuurman,
Kim Sigaloff,
Marry R. Smit,
Cornelis Stijnis,
Willemke Stilma,
Charlotte E. Teunissen,
Patrick Thoral,
Anissa M. Tsonas,
Marc van der Valk,
Denise P. Veelo,
Alexander P. J. Vlaar,
Heder de Vries,
Michèle van Vugt,
W. Joost Wiersinga,
Dorien Wouters,
Aeilko H. Zwinderman,
Saleh Al Muhsen,
Fahd AlMulla,
Mark S. Anderson,
Dusan Bogunovic,
Анастасія Бондаренко,
Yenan T. Bryceson,
Carlos D. Bustamante,
Manish J. Butte,
Samya Chakravorty,
John Christodoulou,
Elizabeth T. Cirulli,
Antônio CondinoNeto,
Megan A. Cooper,
Joseph L. DeRisi,
Murkesh Desai,
Beth A. Drolet,
Sara Espinosa,
José Luis Franco,
Peter K. Gregersen,
David Hagin,
Jim F. Heath,
Sarah E. Henrickson,
Elena W.Y. Hsieh,
Kohsuke Imai,
Yuval Itan,
Timokratis Karamitros,
ChengLung Ku,
Yun Ling,
C. Lucas,
Tom Maniatis,
László Maródi,
Joshua D. Milner,
Kristina Mironska,
Tomohiro Morio,
Giuseppe Novelli,
Antonio Novelli,
Cliona OʼFarrelly,
Satoshi Okada,
Anna M. Planas,
Carolina Prando,
Aurora Pujol,
Laurent Rénia,
Alessandra Renieri,
Vanessa SanchoShimizu,
Vijay G. Sankaran,
Kelly M. Schiabor Barrett,
Mohammed Shahrooei,
Stuart E. Turvey,
K. M. Furkan Uddin,
Mohammed Uddin,
Sara E. Vazquez,
Horst von Bernuth,
Nicole L. Washington,
Paweł Zawadzki
Publication year - 2020
Publication title -
science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 12.556
H-Index - 1186
eISSN - 1095-9203
pISSN - 0036-8075
DOI - 10.1126/science.abd4585
Subject(s) - autoantibody , immunology , asymptomatic , medicine , pneumonia , antibody , phenocopy , coronavirus , disease , covid-19 , biology , infectious disease (medical specialty) , gene , biochemistry , mutant
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
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