Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity | Zendy

Ludovico CantutiCastelvetri | Zendy; Ravi Ojha | Zendy; Liliana D. Pedro | Zendy; Minou Djannatian | Zendy; Jonas Franz | Zendy; Suvi Kuivanen | Zendy; Franziska van der Meer | Zendy; Katri Kallio | Zendy; Tuğberk Kaya | Zendy; Maria Anastasina | Zendy; Teemu Smura | Zendy; Lev Levanov | Zendy; Leonóra Szirovicza | Zendy; Allan Tobi | Zendy; Hannimari KallioKokko | Zendy; Pamela Österlund | Zendy; Merja Joensuu | Zendy; Frédéric A. Meunier | Zendy; Sarah J. Butcher | Zendy; Martin Sebastian Winkler | Zendy; Brit Mollenhauer | Zendy; Ari Helenius | Zendy; Özgün Gökçe | Zendy; Tambet Teesalu | Zendy; Jussi Hepojoki | Zendy; Olli Vapalahti | Zendy; Christine Stadelmann | Zendy; Giuseppe Balistreri | Zendy; Mikael Simons | Zendy

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Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Author(s) -

Ludovico CantutiCastelvetri,

Ravi Ojha,

Liliana D. Pedro,

Minou Djannatian,

Jonas Franz,

Suvi Kuivanen,

Franziska van der Meer,

Katri Kallio,

Tuğberk Kaya,

Maria Anastasina,

Teemu Smura,

Lev Levanov,

Leonóra Szirovicza,

Allan Tobi,

Hannimari KallioKokko,

Pamela Österlund,

Merja Joensuu,

Frédéric A. Meunier,

Sarah J. Butcher,

Martin Sebastian Winkler,

Brit Mollenhauer,

Ari Helenius,

Özgün Gökçe,

Tambet Teesalu,

Jussi Hepojoki,

Olli Vapalahti,

Christine Stadelmann,

Giuseppe Balistreri,

Mikael Simons

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abd2985

Subject(s) - furin , tropism , neuropilin 1 , viral entry , biology , virology , coronavirus , infectivity , virus , protease , tissue tropism , receptor , cell culture , microbiology and biotechnology , viral replication , covid-19 , enzyme , biochemistry , medicine , cancer research , genetics , disease , pathology , infectious disease (medical specialty) , vascular endothelial growth factor , vegf receptors

The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the surface of host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1. A SARS-CoV-2 mutant with an altered furin cleavage site did not depend on NRP1 for infectivity. Pathological analysis of olfactory epithelium obtained from human COVID-19 autopsies revealed that SARS-CoV-2 infected NRP1-positive cells facing the nasal cavity. Our data provide insight into SARS-CoV-2 cell infectivity and define a potential target for antiviral intervention.

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