Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span | Zendy

Myriam Grunewald | Zendy; Saran Kumar | Zendy; Husni Sharife | Zendy; E. Volinsky | Zendy; Alex GilelesHillel | Zendy; Tamar Licht | Zendy; Anna Permyakova | Zendy; Liad Hinden | Zendy; Shahar Azar | Zendy; Yasmin Friedmann | Zendy; P. Kupetz | Zendy; R. Tzuberi | Zendy; Andrey Anisimov | Zendy; Kari Alitalo | Zendy; M. J. Horwitz | Zendy; Shira Leebhoff | Zendy; Oleksiy-Zakhar Khoma | Zendy; Ruslan Hlushchuk | Zendy; Valentin Djonov | Zendy; Rinat Abramovitch | Zendy; Joseph Tam | Zendy; Eli Keshet | Zendy

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Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

Author(s) -

Myriam Grunewald,

Saran Kumar,

Husni Sharife,

E. Volinsky,

Alex GilelesHillel,

Tamar Licht,

Anna Permyakova,

Liad Hinden,

Shahar Azar,

Yasmin Friedmann,

P. Kupetz,

R. Tzuberi,

Andrey Anisimov,

Kari Alitalo,

M. J. Horwitz,

Shira Leebhoff,

Oleksiy-Zakhar Khoma,

Ruslan Hlushchuk,

Valentin Djonov,

Rinat Abramovitch,

Joseph Tam,

Eli Keshet

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abc8479

Subject(s) - sarcopenia , longevity , inflammation , medicine , senescence , osteoporosis , ageing , endocrinology , life span , vascular endothelial growth factor , physiology , vegf receptors , gerontology

More VEGF, more life—and health span Advanced aging is celebrated but its ill effects, deterioration at the cell, tissue, and organ levels, are not. Grunewaldet al . provide evidence for the vascular theory of aging, which reports that age-related decrease of vascular function is a driver of organismal aging at large (see the Perspective by Augustin and Kipnis). Vascular endothelial growth factor (VEGF) signaling insufficiency underlies this vascular insufficiency in aged mice. A modest compensatory increase in circulatory VEGF was sufficient to preserve a young-like vascular homeostasis, alleviate multiple adverse age-related processes, and ameliorate a host of age-associated pathologies in mice. —BAP

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