A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2 | Zendy

Xiangyang Chi | Zendy; Renhong Yan | Zendy; Jun Zhang | Zendy; Guanying Zhang | Zendy; Yuanyuan Zhang | Zendy; Meng Hao | Zendy; Zhe Zhang | Zendy; Pengfei Fan | Zendy; Yunzhu Dong | Zendy; Yilong Yang | Zendy; Zhengshan Chen | Zendy; Yingying Guo | Zendy; Jinlong Zhang | Zendy; Yaning Li | Zendy; Xiaohong Song | Zendy; Yi Chen | Zendy; Lu Xia | Zendy; Ling Fu | Zendy; Lihua Hou | Zendy; Junjie Xu | Zendy; Changming Yu | Zendy; Jianmin Li | Zendy; Qiang Zhou | Zendy; Wei Chen | Zendy

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A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Author(s) -

Xiangyang Chi,

Renhong Yan,

Jun Zhang,

Guanying Zhang,

Yuanyuan Zhang,

Meng Hao,

Zhe Zhang,

Pengfei Fan,

Yunzhu Dong,

Yilong Yang,

Zhengshan Chen,

Yingying Guo,

Jinlong Zhang,

Yaning Li,

Xiaohong Song,

Yi Chen,

Lu Xia,

Ling Fu,

Lihua Hou,

Junjie Xu,

Changming Yu,

Jianmin Li,

Qiang Zhou,

Wei Chen

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abc6952

Subject(s) - spike protein , spike (software development) , terminal (telecommunication) , antibody , covid-19 , virology , chemistry , biology , computer science , immunology , medicine , telecommunications , software engineering , disease , pathology , infectious disease (medical specialty)

Hitting SARS-CoV-2 in a new spot A key target for therapeutic antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the spike protein, a trimeric protein complex with each monomer comprising an S1 and an S2 domain that mediate binding to host cells and membrane fusion, respectively. In addition to the receptor binding domain (RBD), S1 has an N-terminal domain (NTD). In searching for neutralizing antibodies, there has been a focus on the RBD. Chi et al. isolated antibodies from 10 convalescent patients and identified an antibody that potently neutralizes the virus but does not bind the RBD. Cryo–electron microscopy revealed the epitope as the NTD. This NTD-targeting antibody may be useful to combine with RBD-targeting antibodies in therapeutic cocktails. Science , this issue p. 650

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