Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts | Zendy

Jeffrey J. Quinn | Zendy; Matthew G. Jones | Zendy; Ross A. Okimoto | Zendy; Shigeki Nanjo | Zendy; Michelle M. Chan | Zendy; Nir Yosef | Zendy; Trever G. Bivona | Zendy; Jonathan S. Weissman | Zendy

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Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

Author(s) -

Jeffrey J. Quinn,

Matthew G. Jones,

Ross A. Okimoto,

Shigeki Nanjo,

Michelle M. Chan,

Nir Yosef,

Trever G. Bivona,

Jonathan S. Weissman

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abc1944

Subject(s) - metastasis , cancer , cancer metastasis , cancer research , cell , cancer cell , biology , oncology , medicine , genetics

Following cancer through the body The heterogeneity of mammalian tumors has been well documented, but it remains unknown how differences between individual cells lead to metastasis and spread throughout the body. Quinnet al. created a Cas9-based lineage tracer and used single-cell sequencing to generate phylogenies and follow the movement of metastatic human cancer cells implanted in the lung of a mouse xenograph model. Using this model, they found that within the same cell line, cancer cells exhibited diverse metastatic phenotypes. These subclones exhibited differential gene expression profiles, some of which were previously associated with metastasis.Science , this issue p.eabc1944

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