Structure of the RNA-dependent RNA polymerase from COVID-19 virus | Zendy

Yan Gao | Zendy; Liming Yan | Zendy; Yucen Huang | Zendy; Fengjiang Liu | Zendy; Yao Zhao | Zendy; Lin Cao | Zendy; Tao Wang | Zendy; Qianqian Sun | Zendy; Zhenhua Ming | Zendy; Lianqi Zhang | Zendy; Ji Ge | Zendy; Litao Zheng | Zendy; Ying Zhang | Zendy; Haofeng Wang | Zendy; Yan Zhu | Zendy; Chen Zhu | Zendy; Tianyu Hu | Zendy; Tian Hua | Zendy; Bing Zhang | Zendy; Xiuna Yang | Zendy; Jun Li | Zendy; Haitao Yang | Zendy; ZhiJie Liu | Zendy; Wenqing Xu | Zendy; Luke W. Guddat | Zendy; Quan Wang | Zendy; Zhiyong Lou | Zendy; Zihe Rao | Zendy

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Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Author(s) -

Yan Gao,

Liming Yan,

Yucen Huang,

Fengjiang Liu,

Yao Zhao,

Lin Cao,

Tao Wang,

Qianqian Sun,

Zhenhua Ming,

Lianqi Zhang,

Ji Ge,

Litao Zheng,

Ying Zhang,

Haofeng Wang,

Yan Zhu,

Chen Zhu,

Tianyu Hu,

Tian Hua,

Bing Zhang,

Xiuna Yang,

Jun Li,

Haitao Yang,

ZhiJie Liu,

Wenqing Xu,

Luke W. Guddat,

Quan Wang,

Zhiyong Lou,

Zihe Rao

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abb7498

Subject(s) - virology , rna dependent rna polymerase , polymerase , rna polymerase , covid-19 , rna , virus , biology , genetics , gene , medicine , disease , pathology , infectious disease (medical specialty) , outbreak

The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al. focused on a complex that plays a key role in the replication and transcription cycle of the virus. They used cryo–electron microscopy to determine a 2.9-angstrom-resolution structure of the RNA-dependent RNA polymerase nsp12, which catalyzes the synthesis of viral RNA, in complex with two cofactors, nsp7 and nsp8. nsp12 is a target for nucleotide analog antiviral inhibitors such as remdesivir, and the structure may provide a basis for designing new antiviral therapeutics. Science , this issue p. 779

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