Characterization of a common progenitor pool of the epicardium and myocardium | Zendy

Richard C. V. Tyser | Zendy; Ximena Ibarra-Soria | Zendy; Katie McDole | Zendy; Satish Arcot Jayaram | Zendy; Jonathan Godwin | Zendy; Teun van den Brand | Zendy; Antonio M. A. Miranda | Zendy; Antonio Scialdone | Zendy; Philipp Keller | Zendy; John C. Marioni | Zendy; Shankar Srinivas | Zendy

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Characterization of a common progenitor pool of the epicardium and myocardium

Author(s) -

Richard C. V. Tyser,

Ximena Ibarra-Soria,

Katie McDole,

Satish Arcot Jayaram,

Jonathan Godwin,

Teun van den Brand,

Antonio M. A. Miranda,

Antonio Scialdone,

Philipp Keller,

John C. Marioni,

Shankar Srinivas

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abb2986

Subject(s) - characterization (materials science) , progenitor , progenitor cell , business , microbiology and biotechnology , biology , stem cell , nanotechnology , materials science

Forming the early heart The heart is the first organ to form during development and is critical for the survival of the embryo. The precise molecular identities of the various cell types that make up the heart during these early stages remain poorly defined. Tyseret al. used a combination of transcriptomic, imaging, and genetic lineage–labeling approaches to profile the molecular identity and precise locations of cells involved in the formation of the mouse embryonic heart. This approach allowed them to identify the earliest known progenitor of the epicardium, the outermost layer of the heart, which is an important source of signals and cells during cardiac development and injury.Science , this issue p.eabb2986

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