Widespread haploid-biased gene expression enables sperm-level natural selection | Zendy

Kunal Bhutani | Zendy; Katherine Stansifer | Zendy; Simina Ticau | Zendy; Lazar Bojic | Zendy; Alexandra–Chloé Villani | Zendy; Joanna Slisz | Zendy; Claudia M. Cremers | Zendy; Christian Roy | Zendy; Jerry Donovan | Zendy; Brian P. Fiske | Zendy; Robin C. Friedman | Zendy

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Widespread haploid-biased gene expression enables sperm-level natural selection

Author(s) -

Kunal Bhutani,

Katherine Stansifer,

Simina Ticau,

Lazar Bojic,

Alexandra–Chloé Villani,

Joanna Slisz,

Claudia M. Cremers,

Christian Roy,

Jerry Donovan,

Brian P. Fiske,

Robin C. Friedman

Publication year - 2021

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.abb1723

Subject(s) - sperm , biology , ploidy , gene , natural selection , genetics , gene expression , selection (genetic algorithm) , function (biology) , artificial intelligence , computer science

Sperm-specific natural selection Sperm cells are genetically haploid, but because of the cytoplasmic bridges that link cells, they can be transcriptionally diploid. However, some gene transcripts are not shared. Bhutaniet al. sequenced single sperm from mice, cattle, and macaques to determine the extent of distortion in the expression of these putatively selfish transcripts, which the authors call genoinformative markers (GIMs). Investigating the evolutionary pressures on these GIMs, they found that they exhibited signatures of positive selection yet tend to be biased toward sperm function. This observation explains why, relative to other tissues, testis shows distinctive gene expression patterns.Science , this issue p.eabb1723

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