N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription | Zendy

Jun Liu | Zendy; Xiaoyang Dou | Zendy; Chuanyuan Chen | Zendy; Chuan Chen | Zendy; Chang Liu | Zendy; Meng Xu | Zendy; Siqi Zhao | Zendy; Bin Shen | Zendy; Yawei Gao | Zendy; Dali Han | Zendy; Chuan He | Zendy

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N ⁶ -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Author(s) -

Jun Liu,

Xiaoyang Dou,

Chuanyuan Chen,

Chuan Chen,

Chang Liu,

Meng Xu,

Siqi Zhao,

Bin Shen,

Yawei Gao,

Dali Han,

Chuan He

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aay6018

Subject(s) - chromatin , transcription (linguistics) , rna , biology , microbiology and biotechnology , gene , genetics , chemistry , linguistics , philosophy

A new layer of transcriptional control N 6 -methyladenosine (m6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liuet al. now show that m6 A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) in mammalian cells. Disruption of m6 A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m6 A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription.Science , this issue p.580

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