Stem cell–driven lymphatic remodeling coordinates tissue regeneration | Zendy

Shiri GurCohen | Zendy; Hanseul Yang | Zendy; Sanjeethan C. Baksh | Zendy; Yuxuan Miao | Zendy; John M. Levorse | Zendy; Raghu P. Kataru | Zendy; Xiaolei Liu | Zendy; June de la Cruz-Racelis | Zendy; Babak J. Mehrara | Zendy; Elaine Fuchs | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Stem cell–driven lymphatic remodeling coordinates tissue regeneration

Author(s) -

Shiri GurCohen,

Hanseul Yang,

Sanjeethan C. Baksh,

Yuxuan Miao,

John M. Levorse,

Raghu P. Kataru,

Xiaolei Liu,

June de la Cruz-Racelis,

Babak J. Mehrara,

Elaine Fuchs

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aay4509

Subject(s) - lymphatic system , microbiology and biotechnology , regeneration (biology) , biology , niche , lymphangiogenesis , stem cell , homeostasis , anatomy , immunology , ecology , genetics , cancer , metastasis

Stem cells reshape a lymphatic niche Adult stem cells can both self-renew and regenerate new tissue upon demand. They reside in microenvironments (niches) that balance these decisions to avoid tissue overgrowth, cancer, and aging. Using murine skin as a model, Gur-Cohenet al. uncovered a lymphatic network of capillaries associated with the stem cell niche of hair follicles (see the Perspective by Harvey). Stem cells reshaped their lymphatic environment by switching their secretome to coordinate lymphatic-niche association. During tissue regeneration, a dynamic change in epithelial-lymphatic communication remodeled this association, synchronizing stem cell and niche behavior.Science , this issue p.1218 ; see also p.1193

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research