Structure of the RSC complex bound to the nucleosome | Zendy

Youpi Ye | Zendy; Hao Wu | Zendy; Kangjing Chen | Zendy; Cedric R. Clapier | Zendy; Naveen Verma | Zendy; Wenhao Zhang | Zendy; Haiteng Deng | Zendy; Bradley R. Cairns | Zendy; Ning Gao | Zendy; Zhucheng Chen | Zendy

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Structure of the RSC complex bound to the nucleosome

Author(s) -

Youpi Ye,

Hao Wu,

Kangjing Chen,

Cedric R. Clapier,

Naveen Verma,

Wenhao Zhang,

Haiteng Deng,

Bradley R. Cairns,

Ning Gao,

Zhucheng Chen

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aay0033

Subject(s) - chromatin structure remodeling (rsc) complex , nucleosome , chromatin , directionality , computational biology , yeast , chromatin remodeling , modular design , chemistry , biology , microbiology and biotechnology , biophysics , physics , dna , genetics , computer science , operating system

The architecture of the RSC complex RSC is a Snf2-family chromatin remodeler complex that controls the promoter architecture of most of the genes in yeast. Using single-particle cryo–electron microscopy, Yeet al. determined the structure of RSC bound to the nucleosome. The structure reveals the modular architecture of RSC, shows how RSC engages the nucleosome, and explains the remodeling directionality. RSC shows strong similarities to homologous human complexes that are frequently mutated in cancers, and this structure provides valuable information for understanding these systems.Science , this issue p.838

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