REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories | Zendy

Shuntaro Izawa | Zendy; Srikanta Chowdhury | Zendy; Toh Miyazaki | Zendy; Yasutaka Mukai | Zendy; Daisuke Ono | Zendy; Ryo Inoue | Zendy; Yu Ohmura | Zendy; Hiroyuki Mizoguchi | Zendy; Kazuhiro Kimura | Zendy; Mitsuhiro Yoshioka | Zendy; Akira Terao | Zendy; Thomas S. Kilduff | Zendy; Akihiro Yamanaka | Zendy

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REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories

Author(s) -

Shuntaro Izawa,

Srikanta Chowdhury,

Toh Miyazaki,

Yasutaka Mukai,

Daisuke Ono,

Ryo Inoue,

Yu Ohmura,

Hiroyuki Mizoguchi,

Kazuhiro Kimura,

Mitsuhiro Yoshioka,

Akira Terao,

Thomas S. Kilduff,

Akihiro Yamanaka

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aax9238

Subject(s) - forgetting , hippocampus , sleep (system call) , neuroscience , psychology , medicine , cognitive psychology , computer science , operating system

A brain pathway for active forgetting Sleep affects memories via several mechanisms. Izawaet al. identified a possible new pathway in the brain: REM sleep–active hypothalamic melanin-concentrating hormone (MCH)–producing neurons, which, among others, project to the hippocampus. Surprisingly, genetic ablation of MCH neurons increased memory performance in mice. Conversely, pharmacogenetic activation of MCH neurons impaired memory. In vitro physiological experiments showed that activation of MCH fibers in hippocampal slices suppressed spiking activity of pyramidal cells. These findings indicate that the MCH pathway may become a target for memory modulation.Science , this issue p.1308

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