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NAD depletion as pathogen response One way that plants respond to pathogen infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive response carry Toll/interleukin-1 receptor (TIR) domains. In two papers, Horsefieldet al. and Wanet al. report that these TIR domains cleave the metabolic cofactor nicotinamide adenine dinucleotide (NAD+ ) as part of their cell-death signaling in response to pathogens. Similar signaling links mammalian TIR-containing proteins to NAD+ depletion during Wallerian degeneration of neurons.Science , this issue p.793 , p.799

NAD + cleavage activity by animal and plant TIR domains in cell death pathways

NAD ⁺ cleavage activity by animal and plant TIR domains in cell death pathways