Embryonal precursors of Wilms tumor | Zendy

Tim H. H. Coorens | Zendy; Taryn D. Treger | Zendy; Reem AlSaadi | Zendy; Luiza Moore | Zendy; Maxine Tran | Zendy; Thomas J. Mitchell | Zendy; Suzanne Tugnait | Zendy; Christine Thevanesan | Zendy; Matthew D. Young | Zendy; Thomas R. W. Oliver | Zendy; Minou Oostveen | Zendy; Grace Collord | Zendy; Patrick Tarpey | Zendy; Alex Cagan | Zendy; Yvette Hooks | Zendy; Mark Brougham | Zendy; B. C. Reynolds | Zendy; Giuseppe Barone | Zendy; John Anderson | Zendy; Mette Jorgensen | Zendy; G. A. Amos Burke | Zendy; Johannes Visser | Zendy; James C. Nicholson | Zendy; Naima Smeulders | Zendy; Imran Mushtaq | Zendy; Grant D. Stewart | Zendy; Peter J. Campbell | Zendy; David C. Wedge | Zendy; Iñigo Martincorena | Zendy; Dyanne Rampling | Zendy; Liz Hook | Zendy; Anne Y. Warren | Zendy; Nicholas Coleman | Zendy; Tanzina Chowdhury | Zendy; Neil J. Sebire | Zendy; Jarno Drost | Zendy; Kourosh SaebParsy | Zendy; Michael R. Stratton | Zendy; Karin Straathof | Zendy; Kathy PritchardJones | Zendy; Sam Behjati | Zendy

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Embryonal precursors of Wilms tumor

Author(s) -

Tim H. H. Coorens,

Taryn D. Treger,

Reem AlSaadi,

Luiza Moore,

Maxine Tran,

Thomas J. Mitchell,

Suzanne Tugnait,

Christine Thevanesan,

Matthew D. Young,

Thomas R. W. Oliver,

Minou Oostveen,

Grace Collord,

Patrick Tarpey,

Alex Cagan,

Yvette Hooks,

Mark Brougham,

B. C. Reynolds,

Giuseppe Barone,

John Anderson,

Mette Jorgensen,

G. A. Amos Burke,

Johannes Visser,

James C. Nicholson,

Naima Smeulders,

Imran Mushtaq,

Grant D. Stewart,

Peter J. Campbell,

David C. Wedge,

Iñigo Martincorena,

Dyanne Rampling,

Liz Hook,

Anne Y. Warren,

Nicholas Coleman,

Tanzina Chowdhury,

Neil J. Sebire,

Jarno Drost,

Kourosh SaebParsy,

Michael R. Stratton,

Karin Straathof,

Kathy PritchardJones,

Sam Behjati

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aax1323

Subject(s) - wilms' tumor , somatic cell , biology , mutant , cancer , pathology , kidney , cancer research , mutation , genetics , medicine , gene

A childhood tumor—from the beginning Many adult cancers arise from clonal expansions of mutant cells in normal tissue. These premalignant expansions are defined by somatic mutations shared by the cancers. Whether pediatric cancers originate in a similar way is unknown. Coorenset al. studied Wilms tumor, a childhood kidney cancer. Phylogenetic analyses revealed large clones of mutant cells in histologically and functionally normal kidney tissue long before tumor development. Thus, like adult tumors, Wilms tumor appears to arise from a premalignant tissue bed.Science , this issue p.1247

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