Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding | Zendy

Mark A. Rossi | Zendy; Marcus L. Basiri | Zendy; Jenna A. McHenry | Zendy; Oksana Kosyk | Zendy; James M. Otis | Zendy; Hanna E. van den Munkhof | Zendy; Julien Bryois | Zendy; Christopher Hübel | Zendy; Gerome Breen | Zendy; Wilson Guo | Zendy; Cynthia M. Bulik | Zendy; Patrick F. Sullivan | Zendy; Garret D. Stuber | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding

Author(s) -

Mark A. Rossi,

Marcus L. Basiri,

Jenna A. McHenry,

Oksana Kosyk,

James M. Otis,

Hanna E. van den Munkhof,

Julien Bryois,

Christopher Hübel,

Gerome Breen,

Wilson Guo,

Cynthia M. Bulik,

Patrick F. Sullivan,

Garret D. Stuber

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aax1184

Subject(s) - glutamatergic , overeating , obesity , neuroscience , biology , energy homeostasis , optogenetics , endocrinology , medicine , glutamate receptor , receptor , genetics

Brain changes after overeating A brain region called the lateral hypothalamic area is an integral node in the neurocircuitry controlling feeding behavior. In a mouse model of obesity, Rossiet al. found that a distinct class of neurons within this region acts as a brake on feeding, suppressing food intake (see the Perspective by Borgland). These neurons were potently and uniquely modified by diet-induced obesity. Thus, discrete populations of lateral hypothalamic area neurons are fundamental regulators of feeding behavior that might be targeted to treat eating disorders.Science , this issue p.1271 ; see also p.1233

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research