A lipase-independent pathway of lipid release and immune modulation by adipocytes | Zendy

Stephen E Flaherty | Zendy; Ambar Grijalva | Zendy; Xiaoyuan Xu | Zendy; Eleanore Ables | Zendy; Alireza Nomani | Zendy; Anthony W. Ferrante | Zendy

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A lipase-independent pathway of lipid release and immune modulation by adipocytes

Author(s) -

Stephen E Flaherty,

Ambar Grijalva,

Xiaoyuan Xu,

Eleanore Ables,

Alireza Nomani,

Anthony W. Ferrante

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaw2586

Subject(s) - lipase , immune modulation , modulation (music) , immune system , chemistry , lipoprotein lipase , lipid metabolism , adipocyte , biochemistry , microbiology and biotechnology , biology , enzyme , adipose tissue , genetics , physics , acoustics

Exosomes that fatten immune cells Adipose tissue in mammals contains not only adipocytes (fat cells) but also a variety of immune cells—most notably, macrophages. Proper communication between these cell types is thought to be important for metabolic health. Flahertyet al. found that adipocytes release lipid-filled vesicles (AdExos) that serve as the primary source of lipid for adipose-resident macrophages (see the Perspective by Antonyaket al. ). AdExos were present at low levels in the circulation of mice and were produced at twice the rate in obese versus lean animals. In vitro, AdExos induced differentiation of bone marrow precursor cells into cells resembling adipose-resident macrophages.Science , this issue p.989 ; see also p.931

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