A tensile ring drives tissue flows to shape the gastrulating amniote embryo | Zendy

Mehdi Saadaoui | Zendy; Didier Rocancourt | Zendy; Julian Roussel | Zendy; Francis Corson | Zendy; Jérôme Gros | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A tensile ring drives tissue flows to shape the gastrulating amniote embryo

Author(s) -

Mehdi Saadaoui,

Didier Rocancourt,

Julian Roussel,

Francis Corson,

Jérôme Gros

Publication year - 2020

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaw1965

Subject(s) - gastrulation , mesoscopic physics , morphogenesis , primitive streak , embryo , anatomy , germ layer , traveling wave , amniote , physics , biophysics , embryonic stem cell , mechanics , embryogenesis , geometry , chemistry , biology , microbiology and biotechnology , mathematics , mathematical analysis , biochemistry , quantum mechanics , induced pluripotent stem cell , vertebrate , gene

Shaping the early amniote embryo Gastrulation is an essential step in development in which the internal tissues of the body are set apart. In birds and mammals, a similar cascade of molecular events is known to specify embryonic territories, but how they are physically remodeled has remained elusive. Working with avian embryos, Saadaouiet al. identified a cable that encircles the embryo as the engine of gastrulation and described the collective cell movements as similar to the motion of a fluid. One side of this contractile ring pulls more strongly than the other, entraining the large-scale tissue movements that shape the early body plan. The embryo margin, previously known to function in molecular regulation, thus emerges as a dual mechanical and molecular organizer of development.Science , this issue p.453

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research