Dynamic genetic regulation of gene expression during cellular differentiation | Zendy

Benjamin J. Strober | Zendy; Reem Elorbany | Zendy; Katherine Rhodes | Zendy; N. Krishnan | Zendy; Karl Tayeb | Zendy; Alexis Battle | Zendy; Yoav Gilad | Zendy

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Dynamic genetic regulation of gene expression during cellular differentiation

Author(s) -

Benjamin J. Strober,

Reem Elorbany,

Katherine Rhodes,

N. Krishnan,

Karl Tayeb,

Alexis Battle,

Yoav Gilad

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aaw0040

Subject(s) - gene expression , gene , regulation of gene expression , biology , genetics , expression (computer science) , microbiology and biotechnology , cellular differentiation , computational biology , computer science , programming language

Variants affect gene expression over time Genetic variation drives the spectrum of human phenotypes but in some cases has been linked to pathological conditions. Stroberet al. set out to explore how genetic diversity regulates gene expression in cell differentiation over time. They examined expression quantitative trait loci (eQTLS)—genetic variants correlated with gene expression—in induced pluripotent stem cell lines from 19 Yoruban individuals at 16 time points during differentiation into cardiomyocytes. They identified hundreds of developmental stage–specific eQTLs. Thus, the impact of genetic variations depends on the developmental context or tissue under observation.Science , this issue p.1287

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