Major subpopulations of Plasmodium falciparum in sub-Saharan Africa | Zendy

Alfred AmambuaNgwa | Zendy; Lucas Amenga–Etego | Zendy; Edwin Kamau | Zendy; Roberto Amato | Zendy; Anita Ghansah | Zendy; Lemu Golassa | Zendy; Milijaona Randrianarivelojosia | Zendy; Deus S. Ishengoma | Zendy; Tobias O. Apinjoh | Zendy; Oumou MaïgaAscofaré | Zendy; Ben Andagalu | Zendy; William Yavo | Zendy; Marielle Karine Bouyou-Akotet | Zendy; Kolapo Oyebola | Zendy; Karim Mané | Zendy; Archibald Worwui | Zendy; David Jeffries | Zendy; Victoria J. Simpson | Zendy; Umberto D’Alessandro | Zendy; Dominic Kwiatkowski | Zendy; Abdoulaye Djimdé | Zendy

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Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

Author(s) -

Alfred AmambuaNgwa,

Lucas Amenga–Etego,

Edwin Kamau,

Roberto Amato,

Anita Ghansah,

Lemu Golassa,

Milijaona Randrianarivelojosia,

Deus S. Ishengoma,

Tobias O. Apinjoh,

Oumou MaïgaAscofaré,

Ben Andagalu,

William Yavo,

Marielle Karine Bouyou-Akotet,

Kolapo Oyebola,

Karim Mané,

Archibald Worwui,

David Jeffries,

Victoria J. Simpson,

Umberto D’Alessandro,

Dominic Kwiatkowski,

Abdoulaye Djimdé

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aav5427

Subject(s) - malaria , plasmodium falciparum , biology , haplotype , population , genome , genetics , evolutionary biology , gene , genotype , immunology , medicine , environmental health

Ebb and flow of parasite populations The population genetics of the malaria parasitePlasmodium falciparum across Africa is poorly understood but important to know for grasping the risks and dynamics of the spread of drug resistance. Harnessing the power of genomics, Amambua-Ngwaet al. of the Plasmodium Diversity Network Africa found substantial population structure within Africa that is consistent with human and vector population divergence (see the Perspective by Sibley). Specific signatures of selection by antimalarial drugs were detected, along with indications of the effect of colonization and slavery. Furthermore, whole-genome sequencing showed that there is extensive gene flow among the different regions and that Ethiopia has a distinctive population ofP. falciparum , which may be indicative of coexistence with another malaria parasite,P. vivax. Science , this issue p.813 ; see also p.752

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