AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate | Zendy

Qilin Gu | Zendy; Xiaojie Yang | Zendy; Jie Lv | Zendy; Jiaxiong Zhang | Zendy; Bo Xia | Zendy; JunDae Kim | Zendy; Ruoyu Wang | Zendy; Feng Xiong | Zendy; Shu Meng | Zendy; Thomas P. Clements | Zendy; Bhavna Tandon | Zendy; Daniel S. Wagner | Zendy; Miguel F. Diaz | Zendy; Pamela L. Wenzel | Zendy; Yury I. Miller | Zendy; David Traver | Zendy; John P. Cooke | Zendy; Wenbo Li | Zendy; Leonard I. Zon | Zendy; Kaifu Chen | Zendy; Yongping Bai | Zendy; Longhou Fang | Zendy

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AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

Author(s) -

Qilin Gu,

Xiaojie Yang,

Jie Lv,

Jiaxiong Zhang,

Bo Xia,

JunDae Kim,

Ruoyu Wang,

Feng Xiong,

Shu Meng,

Thomas P. Clements,

Bhavna Tandon,

Daniel S. Wagner,

Miguel F. Diaz,

Pamela L. Wenzel,

Yury I. Miller,

David Traver,

John P. Cooke,

Wenbo Li,

Leonard I. Zon,

Kaifu Chen,

Yongping Bai,

Longhou Fang

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aav1749

Subject(s) - notch signaling pathway , biology , haematopoiesis , microbiology and biotechnology , chromatin immunoprecipitation , transcription factor , progenitor cell , stem cell , chromatin , hematopoietic stem cell , signal transduction , genetics , gene , gene expression , promoter

Regulating HSC progenitors via cholesterol Atherosclerosis is characterized by the buildup of cholesterol-containing lipoproteins in the vascular wall. This increased cholesterol augments hematopoietic stem and progenitor cell (HSPC) counts, and the resultant increase in leukocytes is associated with increased cardiovascular disease. Guet al. describe a mechanism orchestrating HSPC specification from the hemogenic endothelium (HE) during embryogenesis (see the Perspective by Rajan and Berman). ApoA-I binding protein accelerated cholesterol efflux from the HE, activating the transcription factor Srebp2, which in turn transactivated Notch signaling. This mechanism also appears to be important for adult HSPC expansion in hypercholesterolemia.Science , this issue p.1085 ; see also p.1041

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