Structural basis of the nucleosome transition during RNA polymerase II passage | Zendy

Tomoya Kujirai | Zendy; Haruhiko Ehara | Zendy; Y. Fujino | Zendy; Mikako Shirouzu | Zendy; Shunichi Sekine | Zendy; Hitoshi Kurumizaka | Zendy

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Structural basis of the nucleosome transition during RNA polymerase II passage

Author(s) -

Tomoya Kujirai,

Haruhiko Ehara,

Y. Fujino,

Mikako Shirouzu,

Shunichi Sekine,

Hitoshi Kurumizaka

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aau9904

Subject(s) - nucleosome , polymerase , transition (genetics) , chemistry , rna polymerase , rna , biology , genetics , microbiology and biotechnology , dna , histone , gene

Nucleosomal DNA transcription In eukaryotes, the basic chromatin unit nucleosome stalls RNA polymerase II (RNAPII) when it transcribes genetic information on DNA. Using cryo–electron microscopy, Kujiraiet al. explored seven structures of the RNAPII-nucleosome complex, in which RNAPII pauses at four locations on the nucleosome. These serial snapshots of the RNAPII progression reveal the molecular mechanism of how RNAPII peels the nucleosomal DNA off the histone stepwise.Science , this issue p.595

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