PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex | Zendy

Wei-Zheng Zeng | Zendy; Kara L. Marshall | Zendy; Soohong Min | Zendy; I. Daou | Zendy; Mark W. Chapleau | Zendy; François M. Abboud | Zendy; Stephen D. Liberles | Zendy; Ardem Patapoutian | Zendy

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PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

Author(s) -

Wei-Zheng Zeng,

Kara L. Marshall,

Soohong Min,

I. Daou,

Mark W. Chapleau,

François M. Abboud,

Stephen D. Liberles,

Ardem Patapoutian

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aau6324

Subject(s) - baroreceptor , piezo1 , baroreflex , nodose ganglion , blood pressure , reflex , reflex bradycardia , optogenetics , medicine , neuroscience , heart rate , anesthesia , biology , ion channel , vagus nerve , receptor , mechanosensitive channels , stimulation

Heart rate and blood pressure control PIEZO1 and PIEZO2 are two mechanically activated ion channels that are highly expressed in lungs, bladder, and skin. Zenget al. found that both ion channels are expressed in sensory neurons of a ganglion complex that contribute to the baroreflex, a homeostatic mechanism that helps to keep blood pressure stable (see the Perspective by Ehmke). Conditional double knockout of PIEZO1 and PIEZO2 in these neurons abolished the baroreflex and disrupted blood pressure regulation and heart rates in mice. These changes were very similar to those seen in patients with baroreflex failure. In mice, selective activation of PIEZO2-expressing ganglion neurons triggered immediate increases in heart rate and blood pressure.Science , this issue p.464 ; see also p.398

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