Hypoxia induces rapid changes to histone methylation and reprograms chromatin | Zendy

Michael Batie | Zendy; Julianty Frost | Zendy; Mark Frost | Zendy; James W. Wilson | Zendy; Pietá Schofield | Zendy; Sónia Rocha | Zendy

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Hypoxia induces rapid changes to histone methylation and reprograms chromatin

Author(s) -

Michael Batie,

Julianty Frost,

Mark Frost,

James W. Wilson,

Pietá Schofield,

Sónia Rocha

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aau5870

Subject(s) - chromatin , hypoxia (environmental) , histone , biology , hypoxia inducible factors , gene expression , transcription factor , epigenetics , regulation of gene expression , gene , microbiology and biotechnology , genetics , oxygen , chemistry , organic chemistry

Oxygen sensing revisited The cellular response to hypoxia (oxygen deficiency) is a contributing factor in many human diseases. Previous studies examining the way in which hypoxia alters gene expression have focused on oxygen-sensing enzymes that regulate the activity of a transcription factor called hypoxia-inducible factor (see the Perspective by Gallipoli and Huntly). Chakrabortyet al. and Batieet al. now show that hypoxia can also affect gene expression through direct effects on chromatin regulators. Certain histone demethylases, such as KDM6A and KDM5A, were found to be direct sensors of oxygen. In cell-culture models, hypoxia diminished the activity of these enzymes and caused changes in the expression of genes that govern cell fate.Science , this issue p.1217 , p.1222 ; see also p.1148

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