Effects of microbiota-directed foods in gnotobiotic animals and undernourished children | Zendy

Jeanette L. Gehrig | Zendy; Siddarth Venkatesh | Zendy; Hao-Wei Chang | Zendy; Martin L. Hibberd | Zendy; Vanderlene L. Kung | Zendy; Jiye Cheng | Zendy; Robert Y. Chen | Zendy; Sathish Subramanian | Zendy; Carrie A. Cowardin | Zendy; Martin Meier | Zendy; David O’Donnell | Zendy; Michael Talcott | Zendy; Larry D. Spears | Zendy; Clay F. Semenkovich | Zendy; Bernard Henrissat | Zendy; Richard J. Gian | Zendy; Robert L. Hettich | Zendy; Olga Ilkayeva | Zendy; Michael J. Muehlbauer | Zendy; Christopher B. Newgard | Zendy; Christopher Sawyer | Zendy; Richard D. Head | Zendy; Dmitry A. Rodionov | Zendy; Aleksandr A. Arzamasov | Zendy; Semen A. Leyn | Zendy; Andrei L. Osterman | Zendy; Md Iqbal Hossain | Zendy; M. Munirul Islam | Zendy; Nuzhat Choudhury | Zendy; Shafiqul Alam Sarker | Zendy; Sayeeda Huq | Zendy; Imteaz Mahmud | Zendy; Ishita Mostafa | Zendy; Mustafa Mahfuz | Zendy; Michael J. Barratt | Zendy; Tahmeed Ahmed | Zendy; Jeffrey I. Gordon | Zendy

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Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Author(s) -

Jeanette L. Gehrig,

Siddarth Venkatesh,

Hao-Wei Chang,

Martin L. Hibberd,

Vanderlene L. Kung,

Jiye Cheng,

Robert Y. Chen,

Sathish Subramanian,

Carrie A. Cowardin,

Martin Meier,

David O’Donnell,

Michael Talcott,

Larry D. Spears,

Clay F. Semenkovich,

Bernard Henrissat,

Richard J. Gian,

Robert L. Hettich,

Olga Ilkayeva,

Michael J. Muehlbauer,

Christopher B. Newgard,

Christopher Sawyer,

Richard D. Head,

Dmitry A. Rodionov,

Aleksandr A. Arzamasov,

Semen A. Leyn,

Andrei L. Osterman,

Md Iqbal Hossain,

M. Munirul Islam,

Nuzhat Choudhury,

Shafiqul Alam Sarker,

Sayeeda Huq,

Imteaz Mahmud,

Ishita Mostafa,

Mustafa Mahfuz,

Michael J. Barratt,

Tahmeed Ahmed,

Jeffrey I. Gordon

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aau4732

Subject(s) - biology , malnutrition , metagenomics , bacteria , weaning , immune system , feces , gut flora , microbiology and biotechnology , severe acute malnutrition , microbiome , immunology , medicine , bioinformatics , endocrinology , biochemistry , genetics , gene

To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.

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