Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinase | Zendy

Gerta Hoxhaj | Zendy; Issam BenSahra | Zendy; Sophie E. Lockwood | Zendy; Rebecca C. Timson | Zendy; Vanessa Byles | Zendy; Graham T. Henning | Zendy; Peng Gao | Zendy; Laura M. Selfors | Zendy; John M. Asara | Zendy; Brendan D. Manning | Zendy

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Direct stimulation of NADP ⁺ synthesis through Akt-mediated phosphorylation of NAD kinase

Author(s) -

Gerta Hoxhaj,

Issam BenSahra,

Sophie E. Lockwood,

Rebecca C. Timson,

Vanessa Byles,

Graham T. Henning,

Peng Gao,

Laura M. Selfors,

John M. Asara,

Brendan D. Manning

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aau3903

Subject(s) - nad+ kinase , nicotinamide adenine dinucleotide phosphate , protein kinase b , cofactor , phosphorylation , nicotinamide adenine dinucleotide , biochemistry , nicotinamide , chemistry , kinase , biology , enzyme , oxidase test

Akt produces reducing power The protein kinase Akt provides a link from growth factors to the production of metabolic reducing power within the cell. Hoxhajet al. discovered that Akt directly phosphorylates nicotinamide adenine dinucleotide kinase (NADK). Catalytic activity of NADK is normally inhibited by its own amino-terminal domain, and phosphorylation by Akt relieved this inhibition. Active NADK produces nicotinamide adenine dinucleotide phosphate (NADP+ ). NADP+ in turn is required to produce the reduced form of NADP+ (NADPH), which is the primary cofactor for reductive metabolism in the cell.Science , this issue p.1088

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