Structural basis for the modulation of voltage-gated sodium channels by animal toxins | Zendy

Huaizong Shen | Zendy; Zhangqiang Li | Zendy; Yan Jiang | Zendy; Xiaojing Pan | Zendy; Jianping Wu | Zendy; Ben CristoforiArmstrong | Zendy; Jennifer J. Smith | Zendy; Yanni K.Y. Chin | Zendy; Jianlin Lei | Zendy; Qiang Zhou | Zendy; Glenn F. King | Zendy; Nieng Yan | Zendy

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Structural basis for the modulation of voltage-gated sodium channels by animal toxins

Author(s) -

Huaizong Shen,

Zhangqiang Li,

Yan Jiang,

Xiaojing Pan,

Jianping Wu,

Ben CristoforiArmstrong,

Jennifer J. Smith,

Yanni K.Y. Chin,

Jianlin Lei,

Qiang Zhou,

Glenn F. King,

Nieng Yan

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aau2596

Subject(s) - saxitoxin , tetrodotoxin , sodium channel , gating , chemistry , toxin , biophysics , marine toxin , neurotoxin , sodium , biology , biochemistry , organic chemistry

Structures of voltage-gated sodium channels In “excitable” cells, like neurons and muscle cells, a difference in electrical potential is used to transmit signals across the cell membrane. This difference is regulated by opening or closing ion channels in the cell membrane. For example, mutations in human voltage-gated sodium (Nav ) channels are associated with disorders such as chronic pain, epilepsy, and cardiac arrhythmia. Panet al. report the high-resolution structure of a human Nav channel, and Shenet al. report the structures of an insect Nav channel bound to the toxins that cause pufferfish and shellfish poisoning in humans. Together, the structures give insight into the molecular basis of sodium ion permeation and provide a path toward structure-based drug discovery.Science , this issue p.eaau2486 , p.eaau2596

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