An ingestible self-orienting system for oral delivery of macromolecules | Zendy

Alex Abramson | Zendy; Ester Caffarel–Salvador | Zendy; Minsoo Khang | Zendy; David Dellal | Zendy; David M. Silverstein | Zendy; Yuan Gao | Zendy; Morten Revsgaard Frederiksen | Zendy; Andreas Vegge | Zendy; František Hubálek | Zendy; Jorrit J. Water | Zendy; Anders V. Friderichsen | Zendy; Johannes Josef Fels | Zendy; Rikke Kaae Kirk | Zendy; Cody Cleveland | Zendy; Joy Collins | Zendy; Siddartha Tamang | Zendy; Alison Hayward | Zendy; Tomas Landh | Zendy; Stephen T. Buckley | Zendy; Niclas Roxhed | Zendy; Ulrik L. Rahbek | Zendy; Róbert Langer | Zendy; Giovanni Traverso | Zendy

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An ingestible self-orienting system for oral delivery of macromolecules

Author(s) -

Alex Abramson,

Ester Caffarel–Salvador,

Minsoo Khang,

David Dellal,

David M. Silverstein,

Yuan Gao,

Morten Revsgaard Frederiksen,

Andreas Vegge,

František Hubálek,

Jorrit J. Water,

Anders V. Friderichsen,

Johannes Josef Fels,

Rikke Kaae Kirk,

Cody Cleveland,

Joy Collins,

Siddartha Tamang,

Alison Hayward,

Tomas Landh,

Stephen T. Buckley,

Niclas Roxhed,

Ulrik L. Rahbek,

Róbert Langer,

Giovanni Traverso

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aau2277

Subject(s) - insulin delivery , food delivery , delivery system , stomach , gastrointestinal tract , nanotechnology , chemistry , medicine , pharmacology , materials science , biochemistry , endocrinology , business , diabetes mellitus , marketing , type 1 diabetes

Delivering fragile drugs to the gut Oral delivery is the simplest and least invasive way to deliver many pharmaceuticals, but many drugs and medications, including insulin, cannot survive passage through the stomach or the gastrointestinal tract. Abramsonet al. developed an ingestible delivery vehicle that could self-reorient from any starting position so as to attach to the gastric wall. Encapsulation of a spring in a sugar casing allowed for triggered actuation for the delivery of biomolecules. The approach successfully provided active insulin delivery in pigs.Science , this issue p.611

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