MCM2 promotes symmetric inheritance of modified histones during DNA replication | Zendy

Nataliya Petryk | Zendy; Maria Dalby | Zendy; Alice Wenger | Zendy; Caroline B. Strømme | Zendy; Anne Strandsby | Zendy; Robin Andersson | Zendy; Anja Groth | Zendy

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MCM2 promotes symmetric inheritance of modified histones during DNA replication

Author(s) -

Nataliya Petryk,

Maria Dalby,

Alice Wenger,

Caroline B. Strømme,

Anne Strandsby,

Robin Andersson,

Anja Groth

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aau0294

Subject(s) - histone , dna replication , sister chromatids , biology , genetics , dna , dna polymerase , helicase , microbiology and biotechnology , chromosome , gene , rna

During genome replication, parental histones are recycled to newly replicated DNA with their posttranslational modifications (PTMs). Whether sister chromatids inherit modified histones evenly remains unknown. We measured histone PTM partition to sister chromatids in embryonic stem cells. We found that parental histones H3-H4 segregate to both daughter DNA strands with a weak leading-strand bias, skewing partition at topologically associating domain (TAD) borders and enhancers proximal to replication initiation zones. Segregation of parental histones to the leading strand increased markedly in cells with histone-binding mutations in MCM2, part of the replicative helicase, exacerbating histone PTM sister chromatid asymmetry. This work reveals how histones are inherited to sister chromatids and identifies a mechanism by which the replication machinery ensures symmetric cell division.

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