Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior | Zendy

Andrea Ganna | Zendy; Karin J. H. Verweij | Zendy; Michel G. Nivard | Zendy; Robert Maier | Zendy; Robbee Wedow | Zendy; Alexander S Busch | Zendy; Abdel Abdellaoui | Zendy; Shengru Guo | Zendy; J. Fah Sathirapongsasuti | Zendy; Paul Lichtenstein | Zendy; Sebastian Lundström | Zendy; Niklas Långström | Zendy; Adam Auton | Zendy; Kathleen Mullan Harris | Zendy; Gary W. Beecham | Zendy; Eden R. Martin | Zendy; Alan R. Sanders | Zendy; John R. B. Perry | Zendy; Benjamin M. Neale | Zendy; Brendan P. Zietsch | Zendy

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Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

Author(s) -

Andrea Ganna,

Karin J. H. Verweij,

Michel G. Nivard,

Robert Maier,

Robbee Wedow,

Alexander S Busch,

Abdel Abdellaoui,

Shengru Guo,

J. Fah Sathirapongsasuti,

Paul Lichtenstein,

Sebastian Lundström,

Niklas Långström,

Adam Auton,

Kathleen Mullan Harris,

Gary W. Beecham,

Eden R. Martin,

Alan R. Sanders,

John R. B. Perry,

Benjamin M. Neale,

Brendan P. Zietsch

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aat7693

Subject(s) - sexual orientation , genetic architecture , genome wide association study , biology , twin study , genetics , inheritance (genetic algorithm) , genetic association , sexual behavior , perspective (graphical) , multifactorial inheritance , evolutionary biology , gene , psychology , heritability , developmental psychology , quantitative trait locus , single nucleotide polymorphism , social psychology , computer science , genotype , artificial intelligence

Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.

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