Salmonella persisters undermine host immune defenses during antibiotic treatment | Zendy

Daphne A. C. Stapels | Zendy; Peter W.S. Hill | Zendy; Alexander J. Westermann | Zendy; Robert A. Fisher | Zendy; Teresa L. M. Thurston | Zendy; AntoineEmmanuel Saliba | Zendy; Isabelle Blommestein | Zendy; Jörg Vogel | Zendy; Sophie Hélaine | Zendy

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Salmonella persisters undermine host immune defenses during antibiotic treatment

Author(s) -

Daphne A. C. Stapels,

Peter W.S. Hill,

Alexander J. Westermann,

Robert A. Fisher,

Teresa L. M. Thurston,

AntoineEmmanuel Saliba,

Isabelle Blommestein,

Jörg Vogel,

Sophie Hélaine

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aat7148

Subject(s) - salmonella , virulence , immune system , microbiology and biotechnology , antibiotics , host (biology) , biology , permissive , macrophage , salmonella infection , immunity , immunology , bacteria , virology , gene , genetics , in vitro

Actively persistentSalmonella A proportion ofSalmonella cells can enter a reversible state of growth arrest, which allows them to tolerate environmental stress such as antibiotics. Stapelset al. found that these cells are not dormant but are actively modulating their environment.Salmonella within their host macrophage niche deployed a specialized type 3 secretory system called SPI-2 to deliver virulence factors, including SteE, into host cells. SteE changed the cytokine profile of the infected macrophages to reprogram them into a noninflammatory and infection-permissive state. Thus, when antibiotics were removed, theSalmonella could reemerge and cause disease.Science , this issue p.1156

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