Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis | Zendy

Mark S. Ladinsky | Zendy; Leandro P. Araújo | Zendy; Xiao Zhang | Zendy; John Veltri | Zendy; Marta Galán-Díez | Zendy; Salima Soualhi | Zendy; Carolyn Lee | Zendy; Koichiro Irie | Zendy; Elisha Y. Pinker | Zendy; Seiko Narushima | Zendy; Sheila Bandyopadhyay | Zendy; Manabu Nagayama | Zendy; Wael Elhenawy | Zendy; Brian K. Coombes | Zendy; Ronaldo P. Ferraris | Zendy; Kenya Honda | Zendy; Iliyan D. Iliev | Zendy; Nan Gao | Zendy; Pamela J. Björkman | Zendy; Ivaylo I. Ivanov | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

Author(s) -

Mark S. Ladinsky,

Leandro P. Araújo,

Xiao Zhang,

John Veltri,

Marta Galán-Díez,

Salima Soualhi,

Carolyn Lee,

Koichiro Irie,

Elisha Y. Pinker,

Seiko Narushima,

Sheila Bandyopadhyay,

Manabu Nagayama,

Wael Elhenawy,

Brian K. Coombes,

Ronaldo P. Ferraris,

Kenya Honda,

Iliyan D. Iliev,

Nan Gao,

Pamela J. Björkman,

Ivaylo I. Ivanov

Publication year - 2019

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aat4042

Subject(s) - endocytosis , microbiology and biotechnology , biology , immune system , segmented filamentous bacteria , cdc42 , antigen , cell , clostridia , immunology , bacteria , signal transduction , biochemistry , genetics , sewage treatment , activated sludge , engineering , waste management

Hooking into antigen transfer Segmented filamentous bacteria (SFB) are anaerobic, spore-forming, clostridia-like organisms that are important immune modulators in the mammalian gut. For some reason, SFB do not provoke inflammatory responses. Ladinskyet al. probed the mechanistic basis of this soothing effect in mice. SFB attach tightly to intestinal epithelial cells via a hook-like structure. Bacterial material is extruded from the hook and enters the host cell by endocytosis. An extruded SFB protein called P3340 is shuttled by the host protein cell division control protein 42 homolog (CDC42) through the endosomelysosome vesicular pathway to the basolateral side of the intestinal epithelial cell. Here, it prompts an immunomodulatory SFB-specific CD4 T helper 17 cell response, possibly via intestinal macrophages.Science , this issue p.eaat4042

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research