Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors | Zendy

Matthew D. Young | Zendy; Thomas J. Mitchell | Zendy; Felipe A. Vieira Braga | Zendy; Maxine Tran | Zendy; Benjamin Stewart | Zendy; John R. Ferdinand | Zendy; Grace Collord | Zendy; Rachel A. Botting | Zendy; Dorin-Mirel Popescu | Zendy; Kevin W. Loudon | Zendy; Roser VentoTormo | Zendy; Emily Stephenson | Zendy; Alex Cagan | Zendy; Sarah J. Farndon | Zendy; Martin Del Castillo VelascoHerrera | Zendy; Charlotte Guzzo | Zendy; Nathan Richoz | Zendy; Lira Mamanova | Zendy; Tevita Aho | Zendy; James N. Armitage | Zendy; Antony C.P. Riddick | Zendy; Imran Mushtaq | Zendy; Stephen Farrell | Zendy; Dyanne Rampling | Zendy; James C. Nicholson | Zendy; Andrew Filby | Zendy; Johanna Burge | Zendy; Steven Lisgo | Zendy; Patrick H. Maxwell | Zendy; Susan Lindsay | Zendy; Anne Y. Warren | Zendy; Grant D. Stewart | Zendy; Neil J. Sebire | Zendy; Nicholas Coleman | Zendy; Muzlifah Haniffa | Zendy; Sarah A. Teichmann | Zendy; Menna R. Clatworthy | Zendy; Sam Behjati | Zendy

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Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

Author(s) -

Matthew D. Young,

Thomas J. Mitchell,

Felipe A. Vieira Braga,

Maxine Tran,

Benjamin Stewart,

John R. Ferdinand,

Grace Collord,

Rachel A. Botting,

Dorin-Mirel Popescu,

Kevin W. Loudon,

Roser VentoTormo,

Emily Stephenson,

Alex Cagan,

Sarah J. Farndon,

Martin Del Castillo VelascoHerrera,

Charlotte Guzzo,

Nathan Richoz,

Lira Mamanova,

Tevita Aho,

James N. Armitage,

Antony C.P. Riddick,

Imran Mushtaq,

Stephen Farrell,

Dyanne Rampling,

James C. Nicholson,

Andrew Filby,

Johanna Burge,

Steven Lisgo,

Patrick H. Maxwell,

Susan Lindsay,

Anne Y. Warren,

Grant D. Stewart,

Neil J. Sebire,

Nicholas Coleman,

Muzlifah Haniffa,

Sarah A. Teichmann,

Menna R. Clatworthy,

Sam Behjati

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aat1699

Subject(s) - transcriptome , identity (music) , cell , kidney , human kidney , biology , microbiology and biotechnology , computational biology , gene , genetics , gene expression , physics , acoustics

Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types, thus providing evidence for the hypothesis that Wilms tumor cells are aberrant fetal cells. In adult renal cell carcinoma, we identified a canonical cancer transcriptome that matched a little-known subtype of proximal convoluted tubular cell. Analyses of the tumor composition defined cancer-associated normal cells and delineated a complex vascular endothelial growth factor (VEGF) signaling circuit. Our findings reveal the precise cellular identities and compositions of human kidney tumors.

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