Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” | Zendy

Neta Shlezinger | Zendy; Henriette Irmer | Zendy; Sourabh Dhingra | Zendy; Sarah R. Beattie | Zendy; Robert A. Cramer | Zendy; Gerhard H. Braus | Zendy; Amir Sharon | Zendy; Tobias M. Hohl | Zendy

Open Access

Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Author(s) -

Neta Shlezinger,

Henriette Irmer,

Sourabh Dhingra,

Sarah R. Beattie,

Robert A. Cramer,

Gerhard H. Braus,

Amir Sharon,

Tobias M. Hohl

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aas9457

Subject(s) - aspergillus fumigatus , programmed cell death , apoptosis , immune system , biology , immunity , immunology , genetics

Aouacheriaet al . question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) inAspergillus fumigatus . Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.

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