NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination | Zendy

Marcus Ruscetti | Zendy; Josef Leibold | Zendy; Matthew Bott | Zendy; Myles Fennell | Zendy; Amanda Kulick | Zendy; Nelson R. Salgado | Zendy; Chi-Chao Chen | Zendy; Yu-Jui Ho | Zendy; Francisco J. SánchezRivera | Zendy; Judith Feucht | Zendy; Timour Baslan | Zendy; Sha Tian | Zendy; Hsuan-An Chen | Zendy; Paul B. Romesser | Zendy; John T. Poirier | Zendy; Charles M. Rudin | Zendy; Elisa de Stanchina | Zendy; Eusebio Manchado | Zendy; Charles J. Sherr | Zendy; Scott W. Lowe | Zendy

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NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

Author(s) -

Marcus Ruscetti,

Josef Leibold,

Matthew Bott,

Myles Fennell,

Amanda Kulick,

Nelson R. Salgado,

Chi-Chao Chen,

Yu-Jui Ho,

Francisco J. SánchezRivera,

Judith Feucht,

Timour Baslan,

Sha Tian,

Hsuan-An Chen,

Paul B. Romesser,

John T. Poirier,

Charles M. Rudin,

Elisa de Stanchina,

Eusebio Manchado,

Charles J. Sherr,

Scott W. Lowe

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aas9090

Subject(s) - cytotoxicity , cancer research , immune system , kras , kinase , immunotherapy , protein kinase a , natural killer cell , lung cancer , cancer cell , cell , biology , cancer , immunology , pharmacology , medicine , microbiology and biotechnology , in vitro , oncology , biochemistry , genetics , colorectal cancer

Small molecules spark NK cell response Immunotherapy is a powerful treatment for certain cancers. Yet for those patients that do not respond, simultaneous strategies that mobilize the immune system and directly target malignant cells may be more effective. Ruscettiet al. report that combining two clinically approved cancer drugs promoted immune surveillance and killing of KRAS-mutant lung tumors in mice (see the Perspective by Cornen and Vivier). The two small molecules—a mitogen-activated protein kinase inhibitor and a cyclin-dependent kinase 4/6 inhibitor—induced natural killer (NK) cell recruitment and elimination of senescent lung cancer cells, which did not occur when either agent was used alone.Science , this issue p.1416 ; see also p.1355

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