Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death” | Zendy

Abdel Aouacheria | Zendy; Kyle W. Cunningham | Zendy; J. Marie Hardwick | Zendy; Zdena Palková | Zendy; Ted Powers | Zendy; Fedor F. Severin | Zendy; Libuše Váchová | Zendy

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Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Author(s) -

Abdel Aouacheria,

Kyle W. Cunningham,

J. Marie Hardwick,

Zdena Palková,

Ted Powers,

Fedor F. Severin,

Libuše Váchová

Publication year - 2018

Publication title -

science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 12.556

H-Index - 1186

eISSN - 1095-9203

pISSN - 0036-8075

DOI - 10.1126/science.aar6910

Subject(s) - aspergillus fumigatus , apoptosis , programmed cell death , aspergillus , autophagy , caspase , immunity , aspergillosis , survivin , biology , protease , pyroptosis , microbiology and biotechnology , immunology , immune system , enzyme , biochemistry

Shlezinger et al (Reports, 8 September 2017, p. 1037) report that the common fungus Aspergillus fumigatus , a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin.

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